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- W2008737991 abstract "This study investigated the effects of trans-resveratrol (trans-3,4′,5-trihydroxystilbene, RESV), a natural polyphenol from grapes with known antioxidant activity, on the respiratory-burst responses and phagocytic activity of rat macrophages. RESV at concentrations of 1–10 μM significantly and dose-dependently inhibited (a) the extracellular production of reactive oxygen intermediates (ROIs) by resident peritoneal macrophages stimulated with phorbol 12-myristate 13-acetate (PMA) (a potent activator of protein kinase C, PKC) and (b) intracellular production of ROIs after opsonin-independent phagocytosis of Kluyveromyces lactis cells. Over the 10–100 μM concentration ranges, RESV likewise inhibited the production of reactive nitrogen intermediates (RNIs) by macrophages stimulated with thioglycollate. RESV concentrations above 10 μM also dose-dependently inhibited the phagocytosis of K. lactis cells. The results obtained demonstrate that RESV is a potent inhibitor of the antipathogen responses of rat macrophages and, thus, suggest that this agent may have applications in the treatment of diseases involving macrophage hyperresponsiveness." @default.
- W2008737991 created "2016-06-24" @default.
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- W2008737991 date "2002-05-01" @default.
- W2008737991 modified "2023-10-17" @default.
- W2008737991 title "Resveratrol modulates rat macrophage functions" @default.
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- W2008737991 doi "https://doi.org/10.1016/s1567-5769(02)00014-0" @default.
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