FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008740996> ?p ?o ?g. }

• W2008740996 endingPage "19" @default.
• W2008740996 startingPage "10" @default.
• W2008740996 abstract "The irradiation of fat results in the formation of 2-alkylcyclobutanones, a new class of food contaminants. Results of previous in vitro studies with primary human colon cells and in vivo experiments with rats fed with 2-alkylcyclobutanones indicated that these radiolytic derivatives may be genotoxic and enhance the progression of colon tumors. The underlying mechanisms of these effects, however, are not clearly understood. Therefore we performed additional investigations to elucidate the genotoxic potential of 2-dodecylcyclobutanone (2dDCB) that is generated from palmitic acid. In particular, we explored the relative sensitivities of human colon cells, representing different stages of tumor development and healthy colon tissues, respectively. HT29clone19A cells, LT97 adenoma cells and primary human epithelial cells were exposed to 2dDCB (150-2097 microM). We determined cytotoxic effects using trypan blue exclusion. Genotoxicity, reflected as strand breaks, was assessed using the alkaline version of the comet assay and chromosomal abnormalities were investigated by 24-color fluorescence-in-situ-hybridization. 2dDCB was cytotoxic in a time- and dose-dependent manner in LT97 adenoma cells and in freshly isolated primary cells but not in the human colon tumor cell line. Associated with this was a marked induction of DNA damage by 2dDCB in LT97 adenoma cells and in freshly isolated colonocytes, whereas in the HT29clone19A cells no strand breaks were detectable. A long-term incubation of LT97 adenoma cells with lower concentrations of 2dDCB revealed cytogenetic effects. In summary, 2dDCB was clearly genotoxic in healthy human colon epithelial cells and in cells representing preneoplastic colon adenoma. These findings provide additional evidence that this compound may be regarded as a possible risk factor for processes in colon carcinogenesis related to initiation and progression." @default.
• W2008740996 created "2016-06-24" @default.
• W2008740996 creator A5027904801 @default.
• W2008740996 creator A5061319253 @default.
• W2008740996 creator A5064854049 @default.
• W2008740996 creator A5069770795 @default.
• W2008740996 creator A5076913706 @default.
• W2008740996 creator A5082558984 @default.
• W2008740996 creator A5086391995 @default.
• W2008740996 date "2006-02-01" @default.
• W2008740996 modified "2023-10-01" @default.
• W2008740996 title "2-Dodecylcyclobutanone, a radiolytic product of palmitic acid, is genotoxic in primary human colon cells and in cells from preneoplastic lesions" @default.
• W2008740996 cites W1246001261 @default.
• W2008740996 cites W1602720693 @default.
• W2008740996 cites W1969683032 @default.
• W2008740996 cites W1973510976 @default.
• W2008740996 cites W1983348338 @default.
• W2008740996 cites W1991376331 @default.
• W2008740996 cites W1997587990 @default.
• W2008740996 cites W2029784055 @default.
• W2008740996 cites W2032864127 @default.
• W2008740996 cites W2035037271 @default.
• W2008740996 cites W2036298023 @default.
• W2008740996 cites W2048341756 @default.
• W2008740996 cites W2060642365 @default.
• W2008740996 cites W2085314737 @default.
• W2008740996 cites W2088053466 @default.
• W2008740996 cites W2091723114 @default.
• W2008740996 cites W2092629964 @default.
• W2008740996 cites W2108209028 @default.
• W2008740996 cites W2110822325 @default.
• W2008740996 cites W2121656629 @default.
• W2008740996 cites W2121749870 @default.
• W2008740996 cites W2127321206 @default.
• W2008740996 cites W2133450689 @default.
• W2008740996 cites W4210989642 @default.
• W2008740996 cites W4232478235 @default.
• W2008740996 cites W4250897382 @default.
• W2008740996 doi "https://doi.org/10.1016/j.mrfmmm.2005.07.015" @default.
• W2008740996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16153665" @default.
• W2008740996 hasPublicationYear "2006" @default.
• W2008740996 type Work @default.
• W2008740996 sameAs 2008740996 @default.
• W2008740996 citedByCount "33" @default.
• W2008740996 countsByYear W20087409962012 @default.
• W2008740996 countsByYear W20087409962014 @default.
• W2008740996 countsByYear W20087409962015 @default.
• W2008740996 countsByYear W20087409962017 @default.
• W2008740996 countsByYear W20087409962018 @default.
• W2008740996 countsByYear W20087409962019 @default.
• W2008740996 countsByYear W20087409962022 @default.
• W2008740996 crossrefType "journal-article" @default.
• W2008740996 hasAuthorship W2008740996A5027904801 @default.
• W2008740996 hasAuthorship W2008740996A5061319253 @default.
• W2008740996 hasAuthorship W2008740996A5064854049 @default.
• W2008740996 hasAuthorship W2008740996A5069770795 @default.
• W2008740996 hasAuthorship W2008740996A5076913706 @default.
• W2008740996 hasAuthorship W2008740996A5082558984 @default.
• W2008740996 hasAuthorship W2008740996A5086391995 @default.
• W2008740996 hasConcept C143425029 @default.
• W2008740996 hasConcept C153911025 @default.
• W2008740996 hasConcept C154317977 @default.
• W2008740996 hasConcept C178790620 @default.
• W2008740996 hasConcept C185592680 @default.
• W2008740996 hasConcept C202751555 @default.
• W2008740996 hasConcept C2777428134 @default.
• W2008740996 hasConcept C2778959862 @default.
• W2008740996 hasConcept C2779936771 @default.
• W2008740996 hasConcept C2780070996 @default.
• W2008740996 hasConcept C2780358455 @default.
• W2008740996 hasConcept C29730261 @default.
• W2008740996 hasConcept C502942594 @default.
• W2008740996 hasConcept C543025807 @default.
• W2008740996 hasConcept C54355233 @default.
• W2008740996 hasConcept C552990157 @default.
• W2008740996 hasConcept C55493867 @default.
• W2008740996 hasConcept C81885089 @default.
• W2008740996 hasConcept C86803240 @default.
• W2008740996 hasConceptScore W2008740996C143425029 @default.
• W2008740996 hasConceptScore W2008740996C153911025 @default.
• W2008740996 hasConceptScore W2008740996C154317977 @default.
• W2008740996 hasConceptScore W2008740996C178790620 @default.
• W2008740996 hasConceptScore W2008740996C185592680 @default.
• W2008740996 hasConceptScore W2008740996C202751555 @default.
• W2008740996 hasConceptScore W2008740996C2777428134 @default.
• W2008740996 hasConceptScore W2008740996C2778959862 @default.
• W2008740996 hasConceptScore W2008740996C2779936771 @default.
• W2008740996 hasConceptScore W2008740996C2780070996 @default.
• W2008740996 hasConceptScore W2008740996C2780358455 @default.
• W2008740996 hasConceptScore W2008740996C29730261 @default.
• W2008740996 hasConceptScore W2008740996C502942594 @default.
• W2008740996 hasConceptScore W2008740996C543025807 @default.
• W2008740996 hasConceptScore W2008740996C54355233 @default.
• W2008740996 hasConceptScore W2008740996C552990157 @default.
• W2008740996 hasConceptScore W2008740996C55493867 @default.
• W2008740996 hasConceptScore W2008740996C81885089 @default.
• W2008740996 hasConceptScore W2008740996C86803240 @default.
• W2008740996 hasIssue "1-2" @default.

• next