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- W2008752249 abstract "Under normal culture conditions, fusion of myoblasts was strictly coordinated with the accumulation of various characteristic muscle enzymes as well as of myosin and actin. Nevertheless, it was not clear whether these two events depended on one another, in other words: is fusion a trigger for myoblast differentiation? We have approached this problem by blocking morphological differentiation by the use of cytochalasin B at the moment when the cells become ‘committed’. It is shown that fusion and accumulation of creatine phosphokinase and phosphorylase can be uncoupled. In view of our results, it seems that fusion is not absolutely necessary for the onset of increased synthesis of muscle-specific enzymes." @default.
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- W2008752249 modified "2023-09-25" @default.
- W2008752249 title "Is fusion a trigger for myoblast differentiation?" @default.
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- W2008752249 doi "https://doi.org/10.1016/0014-4827(75)90480-2" @default.
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