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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008754002> ?p ?o ?g. }

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• W2008754002 abstract "Tenascin-C is an extracellular matrix glycoprotein produced in response to epithelial-mesenchymal interactions during organogenesis and tissue remodelling. It has therefore been proposed as a stromal marker for epithelial malignancy. To test this hypothesis, 30 human lung cancers, presenting a variety of clinicopathological features, and six specimens of normal tissue were examined by Western and Northern blotting of tenascin-C protein and mRNA. The results obtained were: (1) elevated tenascin-C expression was detected in all 30 cases by Western blotting, with mRNA increase in 22 of them; (2) mRNA for a large isoform of tenascin-C, including an alternatively spliced sequence, was expressed in lung cancer tissues but not in normal lungs; and (3) metastasis to lymph nodes was frequently found in cases whose tenascin-C was degraded into small fragments. These results suggest that tenascin-C degradation can be used as a marker for metastatic potential of a tumour." @default.
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• W2008754002 date "1998-01-01" @default.
• W2008754002 modified "2023-10-16" @default.
• W2008754002 title "Expression and degeneration of tenascin-C in human lung cancers" @default.
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• W2008754002 doi "https://doi.org/10.1038/bjc.1998.15" @default.
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