FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008754705> ?p ?o ?g. }

• W2008754705 endingPage "212" @default.
• W2008754705 startingPage "208" @default.
• W2008754705 abstract "Angelica genus (Umbelliferae) has traditionally been used as the medicine and health food considered alleviating several disorders including diabetes mellitus. Angelica hirsutiflora Liu Chao & Chuang is an endemic species and a folk medicine in Taiwan.The scientific evidence of anti-diabetic effect for Angelica hirsutiflora remains unknown. The methanolic extracts isolated from Angelica hirsutiflora were studied for its insulin secretagogue and hypoglycemic activities.The in vitro effects and possible mechanisms of Angelica hirsutiflora extract on the insulin secretion in isolated mouse and human islets and pancreatic beta-cell line HIT-T15 were determined; and tested the regulation of blood glucose in fasted mice and high-fat diet-induced diabetic mice.Angelica hirsutiflora extract potently stimulated the release of insulin from cultured HIT-T15 cells and isolated mouse and human islets. The intracellular calcium levels were also increased in HIT-T15 cells and isolated human islets treated with Angelica hirsutiflora extract. Angelica hirsutiflora extract was capable of enhancing the phosphorylation of extracellular signal-regulated protein kinases (ERK)1/2 protein in HIT-T15 cells. Specific ERK inhibitor PD98059 inhibited the increase of insulin secretion by Angelica hirsutiflora extract in HIT-T15 cells and isolated mouse islets. When Angelica hirsutiflora extract was administered to the fasted mice, it decreased the rise in blood glucose level after starch loading. The plasma insulin level was also increased by Angelica hirsutiflora extract treatment. In high-fat diet-induced diabetic mice, Angelica hirsutiflora extract markedly improved the oral glucose intolerance as compared with the vehicle control.These findings support that Angelica hirsutiflora extract may be useful in the control of hyperglycemia in non-insulin-dependent diabetes mellitus by acting as an insulin secretagogue." @default.
• W2008754705 created "2016-06-24" @default.
• W2008754705 creator A5017385411 @default.
• W2008754705 creator A5022616293 @default.
• W2008754705 creator A5032949945 @default.
• W2008754705 creator A5048784194 @default.
• W2008754705 creator A5054256850 @default.
• W2008754705 creator A5072853276 @default.
• W2008754705 creator A5086650300 @default.
• W2008754705 creator A5088638599 @default.
• W2008754705 date "2009-06-01" @default.
• W2008754705 modified "2023-09-23" @default.
• W2008754705 title "Extract isolated from Angelica hirsutiflora with insulin secretagogue activity" @default.
• W2008754705 cites W1899552864 @default.
• W2008754705 cites W1995527150 @default.
• W2008754705 cites W1997415546 @default.
• W2008754705 cites W2018207206 @default.
• W2008754705 cites W2018895167 @default.
• W2008754705 cites W2021693796 @default.
• W2008754705 cites W2050190427 @default.
• W2008754705 cites W2053176029 @default.
• W2008754705 cites W2061971979 @default.
• W2008754705 cites W2071546758 @default.
• W2008754705 cites W2077434210 @default.
• W2008754705 cites W2100229266 @default.
• W2008754705 cites W2134345431 @default.
• W2008754705 cites W2152993057 @default.
• W2008754705 cites W2170474648 @default.
• W2008754705 cites W2328854942 @default.
• W2008754705 cites W4252152613 @default.
• W2008754705 cites W1523055845 @default.
• W2008754705 doi "https://doi.org/10.1016/j.jep.2009.03.027" @default.
• W2008754705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19429364" @default.
• W2008754705 hasPublicationYear "2009" @default.
• W2008754705 type Work @default.
• W2008754705 sameAs 2008754705 @default.
• W2008754705 citedByCount "17" @default.
• W2008754705 countsByYear W20087547052012 @default.
• W2008754705 countsByYear W20087547052014 @default.
• W2008754705 countsByYear W20087547052015 @default.
• W2008754705 countsByYear W20087547052016 @default.
• W2008754705 countsByYear W20087547052017 @default.
• W2008754705 countsByYear W20087547052018 @default.
• W2008754705 countsByYear W20087547052019 @default.
• W2008754705 countsByYear W20087547052020 @default.
• W2008754705 countsByYear W20087547052021 @default.
• W2008754705 crossrefType "journal-article" @default.
• W2008754705 hasAuthorship W2008754705A5017385411 @default.
• W2008754705 hasAuthorship W2008754705A5022616293 @default.
• W2008754705 hasAuthorship W2008754705A5032949945 @default.
• W2008754705 hasAuthorship W2008754705A5048784194 @default.
• W2008754705 hasAuthorship W2008754705A5054256850 @default.
• W2008754705 hasAuthorship W2008754705A5072853276 @default.
• W2008754705 hasAuthorship W2008754705A5086650300 @default.
• W2008754705 hasAuthorship W2008754705A5088638599 @default.
• W2008754705 hasConcept C126322002 @default.
• W2008754705 hasConcept C134018914 @default.
• W2008754705 hasConcept C142724271 @default.
• W2008754705 hasConcept C188947578 @default.
• W2008754705 hasConcept C204787440 @default.
• W2008754705 hasConcept C2779306644 @default.
• W2008754705 hasConcept C2779454681 @default.
• W2008754705 hasConcept C2779969877 @default.
• W2008754705 hasConcept C2780161494 @default.
• W2008754705 hasConcept C28406088 @default.
• W2008754705 hasConcept C55493867 @default.
• W2008754705 hasConcept C555293320 @default.
• W2008754705 hasConcept C71924100 @default.
• W2008754705 hasConcept C86803240 @default.
• W2008754705 hasConcept C98274493 @default.
• W2008754705 hasConceptScore W2008754705C126322002 @default.
• W2008754705 hasConceptScore W2008754705C134018914 @default.
• W2008754705 hasConceptScore W2008754705C142724271 @default.
• W2008754705 hasConceptScore W2008754705C188947578 @default.
• W2008754705 hasConceptScore W2008754705C204787440 @default.
• W2008754705 hasConceptScore W2008754705C2779306644 @default.
• W2008754705 hasConceptScore W2008754705C2779454681 @default.
• W2008754705 hasConceptScore W2008754705C2779969877 @default.
• W2008754705 hasConceptScore W2008754705C2780161494 @default.
• W2008754705 hasConceptScore W2008754705C28406088 @default.
• W2008754705 hasConceptScore W2008754705C55493867 @default.
• W2008754705 hasConceptScore W2008754705C555293320 @default.
• W2008754705 hasConceptScore W2008754705C71924100 @default.
• W2008754705 hasConceptScore W2008754705C86803240 @default.
• W2008754705 hasConceptScore W2008754705C98274493 @default.
• W2008754705 hasIssue "2" @default.
• W2008754705 hasLocation W20087547051 @default.
• W2008754705 hasLocation W20087547052 @default.
• W2008754705 hasOpenAccess W2008754705 @default.
• W2008754705 hasPrimaryLocation W20087547051 @default.
• W2008754705 hasRelatedWork W2023960546 @default.
• W2008754705 hasRelatedWork W2028214195 @default.
• W2008754705 hasRelatedWork W2042617115 @default.
• W2008754705 hasRelatedWork W2112983599 @default.
• W2008754705 hasRelatedWork W2124921007 @default.
• W2008754705 hasRelatedWork W2129989483 @default.
• W2008754705 hasRelatedWork W2187001057 @default.
• W2008754705 hasRelatedWork W2400635381 @default.

• next