Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008756911> ?p ?o ?g. }
- W2008756911 endingPage "222" @default.
- W2008756911 startingPage "216" @default.
- W2008756911 abstract "A diverse range of diseases involving the reproductive system are treated with luteinizing hormone-releasing hormone (LHRH) agonists which must be administered daily. Currently, an efficient oral delivery system is not available. Here, we show the facile inclusion of lipoamino acids into the peptide sequence of LHRH, rendering it more stable towards enzymatic degradation, as well as enhancing permeability across Caco-2 cell monolayers. Selected LHRH derivatives were tested in vivo by daily oral administration to rats. The size and weight of the sex organs remained unchanged and the levels of LH were stable over the course of the experiment. However, some of the lipidic peptides (3, 8 and 9) were able to reduce serum levels of follicle-stimulating hormone (FSH), an important finding towards the development of orally available LHRH agonists." @default.
- W2008756911 created "2016-06-24" @default.
- W2008756911 creator A5005723083 @default.
- W2008756911 creator A5008581557 @default.
- W2008756911 date "2012-12-01" @default.
- W2008756911 modified "2023-10-16" @default.
- W2008756911 title "Lipidated analogues of luteinizing hormone-releasing hormone (LHRH) reduce serum levels of follicle-stimulating hormone (FSH) after oral administration" @default.
- W2008756911 cites W1567788527 @default.
- W2008756911 cites W1578260220 @default.
- W2008756911 cites W170914365 @default.
- W2008756911 cites W1923034996 @default.
- W2008756911 cites W1963998758 @default.
- W2008756911 cites W1973061187 @default.
- W2008756911 cites W1976687715 @default.
- W2008756911 cites W1976947803 @default.
- W2008756911 cites W1981596044 @default.
- W2008756911 cites W1985279987 @default.
- W2008756911 cites W1985785813 @default.
- W2008756911 cites W1991027240 @default.
- W2008756911 cites W1992569535 @default.
- W2008756911 cites W1992601773 @default.
- W2008756911 cites W1998151033 @default.
- W2008756911 cites W2000289323 @default.
- W2008756911 cites W2002187709 @default.
- W2008756911 cites W2008680174 @default.
- W2008756911 cites W2010082458 @default.
- W2008756911 cites W2014446033 @default.
- W2008756911 cites W2023132559 @default.
- W2008756911 cites W2023138444 @default.
- W2008756911 cites W2030792358 @default.
- W2008756911 cites W2032164167 @default.
- W2008756911 cites W2035919208 @default.
- W2008756911 cites W2036423270 @default.
- W2008756911 cites W2042415727 @default.
- W2008756911 cites W2052543241 @default.
- W2008756911 cites W2055249600 @default.
- W2008756911 cites W2059330646 @default.
- W2008756911 cites W2061105607 @default.
- W2008756911 cites W2072158142 @default.
- W2008756911 cites W2074140598 @default.
- W2008756911 cites W2074344321 @default.
- W2008756911 cites W2080829357 @default.
- W2008756911 cites W2084375116 @default.
- W2008756911 cites W2085264620 @default.
- W2008756911 cites W2089584688 @default.
- W2008756911 cites W2092235725 @default.
- W2008756911 cites W2094742992 @default.
- W2008756911 cites W2123460554 @default.
- W2008756911 cites W2131226468 @default.
- W2008756911 cites W2146417482 @default.
- W2008756911 cites W2292784247 @default.
- W2008756911 cites W2915367047 @default.
- W2008756911 cites W4230106050 @default.
- W2008756911 cites W4254871821 @default.
- W2008756911 doi "https://doi.org/10.1016/j.ijpharm.2012.09.038" @default.
- W2008756911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23022294" @default.
- W2008756911 hasPublicationYear "2012" @default.
- W2008756911 type Work @default.
- W2008756911 sameAs 2008756911 @default.
- W2008756911 citedByCount "6" @default.
- W2008756911 countsByYear W20087569112014 @default.
- W2008756911 countsByYear W20087569112016 @default.
- W2008756911 countsByYear W20087569112017 @default.
- W2008756911 countsByYear W20087569112021 @default.
- W2008756911 crossrefType "journal-article" @default.
- W2008756911 hasAuthorship W2008756911A5005723083 @default.
- W2008756911 hasAuthorship W2008756911A5008581557 @default.
- W2008756911 hasConcept C126322002 @default.
- W2008756911 hasConcept C134018914 @default.
- W2008756911 hasConcept C150903083 @default.
- W2008756911 hasConcept C185592680 @default.
- W2008756911 hasConcept C207001950 @default.
- W2008756911 hasConcept C2777056448 @default.
- W2008756911 hasConcept C2778575703 @default.
- W2008756911 hasConcept C2778894405 @default.
- W2008756911 hasConcept C2779279165 @default.
- W2008756911 hasConcept C71315377 @default.
- W2008756911 hasConcept C71924100 @default.
- W2008756911 hasConcept C86803240 @default.
- W2008756911 hasConcept C98274493 @default.
- W2008756911 hasConceptScore W2008756911C126322002 @default.
- W2008756911 hasConceptScore W2008756911C134018914 @default.
- W2008756911 hasConceptScore W2008756911C150903083 @default.
- W2008756911 hasConceptScore W2008756911C185592680 @default.
- W2008756911 hasConceptScore W2008756911C207001950 @default.
- W2008756911 hasConceptScore W2008756911C2777056448 @default.
- W2008756911 hasConceptScore W2008756911C2778575703 @default.
- W2008756911 hasConceptScore W2008756911C2778894405 @default.
- W2008756911 hasConceptScore W2008756911C2779279165 @default.
- W2008756911 hasConceptScore W2008756911C71315377 @default.
- W2008756911 hasConceptScore W2008756911C71924100 @default.
- W2008756911 hasConceptScore W2008756911C86803240 @default.
- W2008756911 hasConceptScore W2008756911C98274493 @default.
- W2008756911 hasFunder F4320334704 @default.
- W2008756911 hasIssue "1-2" @default.
- W2008756911 hasLocation W20087569111 @default.
- W2008756911 hasLocation W20087569112 @default.
- W2008756911 hasOpenAccess W2008756911 @default.