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• W2008771657 abstract "In the tilapia, Oreochromis niloticus, sex is determined by genetic factors (XX/XY) but temperature can also influence the gonadal sex differentiation. Elevated temperatures of 35 degrees C can generate functional male phenotypes if applied before and during sexual differentiation. The genes and mechanisms by which temperature acts on the cascade leading to sex differentiation have been investigated. Two strategies have been followed: 1) Search for novel genes by differential display, and 2) Expression studies of candidate genes. Genetically all-female and all-male progenies were reared at 27 degrees C (natural temperature) and at 35 degrees C (masculinizing treatment) and gonads dissected. Using differential display, we isolated a 300 bp cDNA (MM20C) from temperature-masculinized females. Virtual northern analysis revealed a 1.2 kb transcript in 35 degrees C treated females and males, but hardly any expression in natural females (27 degrees C). Semi-quantitative RT-PCR established a several-fold increase in MM20C expression in 35 degrees C masculinized fry. Elevated expression was observed in natural males (27 degrees C) with higher levels detected in those reared at 35 degrees C. Furthermore, we have analyzed as a candidate gene the P450 11beta-hydroxylase, an important androgen steroidogenic enzyme. Low levels of expression were found in natural males. This coincides with low concentrations of 11 ketotestosterone in the gonads before and during gonadal sex differentiation. Higher expression levels of 11beta-hydroxylase were detected in male gonads at 35 degrees C but levels in phenotypic males were similar to those found for natural females. Previous results reported that expression of aromatase is repressed by masculinizing treatments. Our study demonstrated that masculinizing-temperature can also stimulate the expression of other gene(s)." @default.
• W2008771657 created "2016-06-24" @default.
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• W2008771657 date "2001-01-01" @default.
• W2008771657 modified "2023-10-18" @default.
• W2008771657 title "Search for genes involved in the temperature-induced gonadal sex differentiation in the tilapia,Oreochromis niloticus" @default.
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• W2008771657 doi "https://doi.org/10.1002/jez.1108" @default.
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