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• W2008777875 abstract "Combined estrogen-progestogen oral contraceptives (OC) have been shown to alter the metabolism of certain drugs, including corticosteroids, as well as affect circulating protein concentrations. To assess these effects with regard to prednisolone, the pharmacokinetics and protein binding of this steroid were evaluated in eight female OC users and compared with results from eight male and five female non-OC users. All volunteers received 40 mg prednisolone, iv, and steroid concentrations were measured by high pressure liquid chromatography. Plasma clearance of total prednisolone in females on OC was 96 ± 9 (SD) ml/min·1.73 m2, significantly (P < 0.001) lower than those in both male and female controls (205 ± 46 and 187 ± 22 ml/min·1.73 m2). The prednisolone half-life and mean residence time were longer, while the steady state volume of distribution was smaller for OC users. Unbound prednisolone was measured by equilibrium dialysis, and pharmacokinetic and protein binding parameters were calculated from free prednisolone concentrations. A significantly higher (2-fold) concentration of transcortin was found in OC users. Evaluation of free prednisolone parameters showed a significantly lower clearance and decreased volume of distribution, without alteration of the mean residence time for the OC users. Dual OC effects on binding and elimination of prednisolone occur with the net result of a 2-fold increase in the area under the free concentration-time curve, indicative of a marked reduction in the biotransformation rate of the steroid. (J Clin Endocrinol Metab56: 702, 1983)" @default.
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• W2008777875 date "1983-04-01" @default.
• W2008777875 modified "2023-10-14" @default.
• W2008777875 title "Prednisolone Disposition and Protein Binding in Oral Contraceptive Users*" @default.
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• W2008777875 doi "https://doi.org/10.1210/jcem-56-4-702" @default.
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