FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008779719> ?p ?o ?g. }

• W2008779719 endingPage "701" @default.
• W2008779719 startingPage "693" @default.
• W2008779719 abstract "Cytochromes P450 2B1 and 2B2 (CYP2B1 and CYP2B2) are well-known phenobarbital-inducible genes in rat liver. Potential transcriptional regulatory elements in the proximal promoter regions of rat CYP2B genes were analyzed by transfection in HepG2 hepatoma cells and by binding of nuclear proteins. Deletion of sequences from -1,400 to -110 had modest effects on promoter activity, but further deletion to -57 decreased the transcriptional activity by more than 90%, suggesting the presence of strong cis-acting elements in this region. Sequences similar to a basal transcription element (BTE) in CYP1A1 and a proposed phenobarbital responsive element (Barbie box) are present from -89 to -67. However, no protection was detected in these regions by DNase I footprinting assay. Instead, a region (FP1) from -64 to -45 was protected by liver nuclear extracts. Mutation of either the BTE or FP1 sequences of CYP2B1, or both, reduced transcriptional activity by 70-80% in HepG2 cells. FP1 was identified as a functional C/EBP site by co-transfection of C/EBP expression vectors and supershift assays with C/EBP antisera. Binding of liver nuclear proteins to sequences within the -110 to +1 region was not detectably altered by pretreatment of rats with phenobarbital." @default.
• W2008779719 created "2016-06-24" @default.
• W2008779719 creator A5026464156 @default.
• W2008779719 creator A5061052298 @default.
• W2008779719 date "1996-08-01" @default.
• W2008779719 modified "2023-10-12" @default.
• W2008779719 title "The<i>CYP2B1</i>Proximal Promoter Contains a Functional C/EBP Regulatory Element" @default.
• W2008779719 cites W1505708538 @default.
• W2008779719 cites W1512266787 @default.
• W2008779719 cites W1515769111 @default.
• W2008779719 cites W1525417539 @default.
• W2008779719 cites W1532432516 @default.
• W2008779719 cites W1542297760 @default.
• W2008779719 cites W1549118099 @default.
• W2008779719 cites W1558516755 @default.
• W2008779719 cites W1592745274 @default.
• W2008779719 cites W1598477767 @default.
• W2008779719 cites W1614919593 @default.
• W2008779719 cites W1616231405 @default.
• W2008779719 cites W1824191488 @default.
• W2008779719 cites W1965258786 @default.
• W2008779719 cites W1977376984 @default.
• W2008779719 cites W1981907620 @default.
• W2008779719 cites W1988059168 @default.
• W2008779719 cites W1993243592 @default.
• W2008779719 cites W2005019916 @default.
• W2008779719 cites W2007522990 @default.
• W2008779719 cites W2032057105 @default.
• W2008779719 cites W2043263657 @default.
• W2008779719 cites W2044639011 @default.
• W2008779719 cites W2056887187 @default.
• W2008779719 cites W2062589966 @default.
• W2008779719 cites W2071230117 @default.
• W2008779719 cites W2076134621 @default.
• W2008779719 cites W2076682110 @default.
• W2008779719 cites W2082199182 @default.
• W2008779719 cites W2085837116 @default.
• W2008779719 cites W2088622701 @default.
• W2008779719 cites W2089597112 @default.
• W2008779719 cites W2093617423 @default.
• W2008779719 cites W2102074140 @default.
• W2008779719 cites W2119577005 @default.
• W2008779719 cites W2126093778 @default.
• W2008779719 cites W2133867412 @default.
• W2008779719 cites W2136066768 @default.
• W2008779719 cites W2149935989 @default.
• W2008779719 cites W2152037670 @default.
• W2008779719 cites W2888511473 @default.
• W2008779719 doi "https://doi.org/10.1089/dna.1996.15.693" @default.
• W2008779719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8769571" @default.
• W2008779719 hasPublicationYear "1996" @default.
• W2008779719 type Work @default.
• W2008779719 sameAs 2008779719 @default.
• W2008779719 citedByCount "43" @default.
• W2008779719 countsByYear W20087797192012 @default.
• W2008779719 countsByYear W20087797192016 @default.
• W2008779719 countsByYear W20087797192018 @default.
• W2008779719 countsByYear W20087797192019 @default.
• W2008779719 crossrefType "journal-article" @default.
• W2008779719 hasAuthorship W2008779719A5026464156 @default.
• W2008779719 hasAuthorship W2008779719A5061052298 @default.
• W2008779719 hasConcept C101762097 @default.
• W2008779719 hasConcept C104317684 @default.
• W2008779719 hasConcept C132376346 @default.
• W2008779719 hasConcept C138885662 @default.
• W2008779719 hasConcept C150194340 @default.
• W2008779719 hasConcept C153911025 @default.
• W2008779719 hasConcept C165864922 @default.
• W2008779719 hasConcept C179926584 @default.
• W2008779719 hasConcept C21592294 @default.
• W2008779719 hasConcept C22427896 @default.
• W2008779719 hasConcept C27153228 @default.
• W2008779719 hasConcept C2778021871 @default.
• W2008779719 hasConcept C41895202 @default.
• W2008779719 hasConcept C54009773 @default.
• W2008779719 hasConcept C54355233 @default.
• W2008779719 hasConcept C86339819 @default.
• W2008779719 hasConcept C86803240 @default.
• W2008779719 hasConceptScore W2008779719C101762097 @default.
• W2008779719 hasConceptScore W2008779719C104317684 @default.
• W2008779719 hasConceptScore W2008779719C132376346 @default.
• W2008779719 hasConceptScore W2008779719C138885662 @default.
• W2008779719 hasConceptScore W2008779719C150194340 @default.
• W2008779719 hasConceptScore W2008779719C153911025 @default.
• W2008779719 hasConceptScore W2008779719C165864922 @default.
• W2008779719 hasConceptScore W2008779719C179926584 @default.
• W2008779719 hasConceptScore W2008779719C21592294 @default.
• W2008779719 hasConceptScore W2008779719C22427896 @default.
• W2008779719 hasConceptScore W2008779719C27153228 @default.
• W2008779719 hasConceptScore W2008779719C2778021871 @default.
• W2008779719 hasConceptScore W2008779719C41895202 @default.
• W2008779719 hasConceptScore W2008779719C54009773 @default.
• W2008779719 hasConceptScore W2008779719C54355233 @default.
• W2008779719 hasConceptScore W2008779719C86339819 @default.
• W2008779719 hasConceptScore W2008779719C86803240 @default.
• W2008779719 hasIssue "8" @default.
• W2008779719 hasLocation W20087797191 @default.
• W2008779719 hasLocation W20087797192 @default.

• next