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• W2008785284 abstract "The effect of candesartan, an angiotensin-II type-1 receptor antagonist, on the metabolic profile and renal inflammation is unclear. We evaluated this relationship by feeding male lean (LZ) and obese (OZ) Zucker rats chow or chow with candesartan (23.5 mg/<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mtext>kg</mml:mtext><mml:mo>⋅</mml:mo><mml:mtext>diet</mml:mtext></mml:mrow></mml:math>) for 14 weeks (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn></mml:mrow></mml:math>–8/treatment/body type). Candesartan reduced serum triglycerides, plasma creatinine, urine albumin, and renal cortical collagen and glycogen deposition in the OZ. An ELISA-based cytokine array revealed that candesartan normalized elevated renal interleukin (IL) 1-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>and monocyte chemoattractant protein-1 (MCP-1) levels in OZ. Nonetheless, candesartan impaired glucose tolerance, and did not lower blood insulin or glucose levels. Moreover, renal IL-1<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, -2, -4, -6 and -10 tumor necrosis factor-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, interferon-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>γ</mml:mi></mml:math>, were significantly reduced in OZ relative to LZ, and increased by candesartan. Furthermore, candesartan increased growth-regulated oncogene, transforming growth factor-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>1 and IL-18 in OZ kidneys to a level higher than LZ or untreated OZ. Candesartan did not affect renal cytokine levels in LZ. Overall, candesartan attenuated renal disease and improved renal function in OZ, despite mixed effects on metabolic factors and cytokines. Reduced plasma triglycerides and/or renal MCP-1 and IL-1<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>may have had a role in this protection. However, these effects were clearly independent of any improvement in glucose tolerance." @default.
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• W2008785284 date "2010-01-01" @default.
• W2008785284 modified "2023-09-25" @default.
• W2008785284 title "The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat" @default.
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• W2008785284 doi "https://doi.org/10.1155/2010/841343" @default.
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