FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008789744> ?p ?o ?g. }

• W2008789744 endingPage "519" @default.
• W2008789744 startingPage "514" @default.
• W2008789744 abstract "REDD1 (Regulated in Development and DNA Damage-1) is a stress-response gene that represses mammalian target of rapamycin (mTOR) thus decreasing protein synthesis. In contrast to studies using cell lines and adult alveolar type II (ATII) cells, we find that REDD1 mRNA levels did not increase in rat fetal distal lung epithelia (FDLE) or fetal lung fibroblasts grown in primary cultures and then exposed to 3% O2. REDD1 mRNA expression was repressed by dexamethasone (DEX) in FDLE and ATII, but induced by DEX in fibroblasts. Lung epithelial cell lines, A549 and MLE-15, showed increases in REDD1 mRNA in response to hypoxia and DEX. The effect of DEX on REDD1 mRNA and protein in FDLE and fibroblasts was dose- and time-dependent. Inhibitor studies support repression of REDD1 mRNA by DEX in FDLE was mediated via glucocorticoid receptor and not by nongenomic effects of glucocorticoids via MAPK pathways. The half-life of REDD1 mRNA was shorter in DEX-exposed FDLE compared with hormone-free media suggesting that DEX reduced REDD1 mRNA stability in FDLE. These studies indicate that REDD1 expression in response to hypoxia and DEX is cell-type specific and that physiologically appropriate levels of PO2 should be used when investigating fetal lung development." @default.
• W2008789744 created "2016-06-24" @default.
• W2008789744 creator A5003526598 @default.
• W2008789744 creator A5003840739 @default.
• W2008789744 creator A5029330464 @default.
• W2008789744 creator A5037533913 @default.
• W2008789744 creator A5051215323 @default.
• W2008789744 date "2009-05-01" @default.
• W2008789744 modified "2023-10-16" @default.
• W2008789744 title "Glucocorticoid-Mediated Repression of REDD1 mRNA Expression in Rat Fetal Distal Lung Epithelial Cells" @default.
• W2008789744 cites W1970976586 @default.
• W2008789744 cites W1980026775 @default.
• W2008789744 cites W1984852534 @default.
• W2008789744 cites W1985850338 @default.
• W2008789744 cites W1991824971 @default.
• W2008789744 cites W1992533386 @default.
• W2008789744 cites W1998750778 @default.
• W2008789744 cites W2001674978 @default.
• W2008789744 cites W2009721053 @default.
• W2008789744 cites W2023456818 @default.
• W2008789744 cites W2047142238 @default.
• W2008789744 cites W2058156143 @default.
• W2008789744 cites W2058239750 @default.
• W2008789744 cites W2077001140 @default.
• W2008789744 cites W2079195253 @default.
• W2008789744 cites W2080447685 @default.
• W2008789744 cites W2087262125 @default.
• W2008789744 cites W2090950464 @default.
• W2008789744 cites W2093341871 @default.
• W2008789744 cites W2095831813 @default.
• W2008789744 cites W2101208037 @default.
• W2008789744 cites W2101991847 @default.
• W2008789744 cites W2107567984 @default.
• W2008789744 cites W2108733798 @default.
• W2008789744 cites W2115820946 @default.
• W2008789744 cites W2119788597 @default.
• W2008789744 cites W2145906341 @default.
• W2008789744 cites W2160082612 @default.
• W2008789744 cites W2166567860 @default.
• W2008789744 cites W2187076610 @default.
• W2008789744 cites W2341429764 @default.
• W2008789744 doi "https://doi.org/10.1203/pdr.0b013e3181998db6" @default.
• W2008789744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19127203" @default.
• W2008789744 hasPublicationYear "2009" @default.
• W2008789744 type Work @default.
• W2008789744 sameAs 2008789744 @default.
• W2008789744 citedByCount "11" @default.
• W2008789744 countsByYear W20087897442012 @default.
• W2008789744 countsByYear W20087897442013 @default.
• W2008789744 countsByYear W20087897442015 @default.
• W2008789744 countsByYear W20087897442016 @default.
• W2008789744 countsByYear W20087897442018 @default.
• W2008789744 countsByYear W20087897442019 @default.
• W2008789744 countsByYear W20087897442020 @default.
• W2008789744 countsByYear W20087897442021 @default.
• W2008789744 countsByYear W20087897442022 @default.
• W2008789744 crossrefType "journal-article" @default.
• W2008789744 hasAuthorship W2008789744A5003526598 @default.
• W2008789744 hasAuthorship W2008789744A5003840739 @default.
• W2008789744 hasAuthorship W2008789744A5029330464 @default.
• W2008789744 hasAuthorship W2008789744A5037533913 @default.
• W2008789744 hasAuthorship W2008789744A5051215323 @default.
• W2008789744 hasBestOaLocation W20087897441 @default.
• W2008789744 hasConcept C104317684 @default.
• W2008789744 hasConcept C105580179 @default.
• W2008789744 hasConcept C126322002 @default.
• W2008789744 hasConcept C134018914 @default.
• W2008789744 hasConcept C150194340 @default.
• W2008789744 hasConcept C153911025 @default.
• W2008789744 hasConcept C172680121 @default.
• W2008789744 hasConcept C178790620 @default.
• W2008789744 hasConcept C185592680 @default.
• W2008789744 hasConcept C186310378 @default.
• W2008789744 hasConcept C2779234561 @default.
• W2008789744 hasConcept C2780401358 @default.
• W2008789744 hasConcept C2780841215 @default.
• W2008789744 hasConcept C540031477 @default.
• W2008789744 hasConcept C54355233 @default.
• W2008789744 hasConcept C55493867 @default.
• W2008789744 hasConcept C59493245 @default.
• W2008789744 hasConcept C62478195 @default.
• W2008789744 hasConcept C71924100 @default.
• W2008789744 hasConcept C7836513 @default.
• W2008789744 hasConcept C81885089 @default.
• W2008789744 hasConcept C86554907 @default.
• W2008789744 hasConcept C86803240 @default.
• W2008789744 hasConcept C95444343 @default.
• W2008789744 hasConceptScore W2008789744C104317684 @default.
• W2008789744 hasConceptScore W2008789744C105580179 @default.
• W2008789744 hasConceptScore W2008789744C126322002 @default.
• W2008789744 hasConceptScore W2008789744C134018914 @default.
• W2008789744 hasConceptScore W2008789744C150194340 @default.
• W2008789744 hasConceptScore W2008789744C153911025 @default.
• W2008789744 hasConceptScore W2008789744C172680121 @default.
• W2008789744 hasConceptScore W2008789744C178790620 @default.
• W2008789744 hasConceptScore W2008789744C185592680 @default.
• W2008789744 hasConceptScore W2008789744C186310378 @default.
• W2008789744 hasConceptScore W2008789744C2779234561 @default.

• next