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• W2008795411 endingPage "1649" @default.
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• W2008795411 abstract "Complex carbohydrates and sugar receptors at the surface of eukaryotic cells are involved in recognition phenomena. Membrane lectins have been characterized, using biochemical, biological and cytological methods. Their biological activities have been assessed using labeled glycoproteins or neoglycoproteins. Specific glycoproteins or neoglycoproteins have been used to inhibit their binding capacity in both in vitro and in vivo experiments. In adults, lymphoid and myeloid cells as well as tumor cells grow in a given organ and eventually migrate and home in another organ; these phenomena are known as the homing process or metastasis, respectively. In specific cases, membrane lectins of endothelial cells recognize cell surface glycoconjugates of lymphocytes or tumor cells, while membrane lectins of lymphocytes and of tumor cells recognize glycoconjugates of extracellular matrices or of non-migrating cells. Therefore, membrane lectins are involved in cell-cell recognition phenomena. Membrane lectins are also involved in endocytosis and intracellular traffic of glycoconjugates. This property has been demonstrated not only in hepatocytes, fibroblasts, macrophages and histiocytes but also in tumor cells, monocytes, thyrocytes, etc. Upon endocytosis, membrane lectins are present in endosomes, whose luminal pH rapidly decreases. In cells such as tumor cells or macrophages, endosomes fuse with lysosomes; it is therefore possible to target cytotoxic drugs or activators, by binding them to specific glycoconjugates or neoglycoproteins through a linkage specifically hydrolyzed by lysosomal enzymes. In cells such as monocytes, the delivery of glycoconjugates to lysosomes is not active; in this case, it would be preferable to use an acid-labile linkage. Cell surface membrane lectins are developmentally regulated; they are present at given stages of differentiation and of malignant transformation. Cell surface membrane lectins usually bind glycoconjugates at neutral pH but not in acidic medium: their ligand is released in acidic specialized organelles; the internalized ligand may be then delivered into lysosomes, while the membrane lectin is recycled. Some membrane lectins, however, do bind their ligand in relatively acidic medium as in the case of thyrocytes. The presence of cell surface membrane lectins which recognize specific sugar moieties opens the way to interesting applications: for instanve, isolation of cell subpopulations such as human suppressor T cells, targeting of anti-tumor or anti-viral drugs, targeting of immunomodulators or biological response modifiers." @default.
• W2008795411 created "2016-06-24" @default.
• W2008795411 creator A5022255574 @default.
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• W2008795411 creator A5071251708 @default.
• W2008795411 date "1988-11-01" @default.
• W2008795411 modified "2023-09-27" @default.
• W2008795411 title "Characterization and biological implications of membrane lectins in tumor, lymphoid and myeloid cells" @default.
• W2008795411 cites W107998760 @default.
• W2008795411 cites W131247432 @default.
• W2008795411 cites W1480177624 @default.
• W2008795411 cites W1482559745 @default.
• W2008795411 cites W1483862981 @default.
• W2008795411 cites W1489195678 @default.
• W2008795411 cites W1493832020 @default.
• W2008795411 cites W1505476546 @default.
• W2008795411 cites W1513081562 @default.
• W2008795411 cites W1515230561 @default.
• W2008795411 cites W1523963034 @default.
• W2008795411 cites W1529241707 @default.
• W2008795411 cites W1533643153 @default.
• W2008795411 cites W1534299725 @default.
• W2008795411 cites W1561752228 @default.
• W2008795411 cites W1576045239 @default.
• W2008795411 cites W1576435778 @default.
• W2008795411 cites W1583080588 @default.
• W2008795411 cites W1597133673 @default.
• W2008795411 cites W1664376284 @default.
• W2008795411 cites W1950671087 @default.
• W2008795411 cites W1964839075 @default.
• W2008795411 cites W1966435697 @default.
• W2008795411 cites W1970118006 @default.
• W2008795411 cites W1971899594 @default.
• W2008795411 cites W1974343165 @default.
• W2008795411 cites W1974906702 @default.
• W2008795411 cites W1976078610 @default.
• W2008795411 cites W1976551683 @default.
• W2008795411 cites W1977035727 @default.
• W2008795411 cites W1979901510 @default.
• W2008795411 cites W1980183488 @default.
• W2008795411 cites W1980427216 @default.
• W2008795411 cites W1981621217 @default.
• W2008795411 cites W1981733663 @default.
• W2008795411 cites W1982832452 @default.
• W2008795411 cites W1985157666 @default.
• W2008795411 cites W1985634516 @default.
• W2008795411 cites W1986216396 @default.
• W2008795411 cites W1987016786 @default.
• W2008795411 cites W1989902354 @default.
• W2008795411 cites W1992117222 @default.
• W2008795411 cites W1992675608 @default.
• W2008795411 cites W1994330593 @default.
• W2008795411 cites W1994506075 @default.
• W2008795411 cites W1994695339 @default.
• W2008795411 cites W1995147267 @default.
• W2008795411 cites W1995637046 @default.
• W2008795411 cites W1997550663 @default.
• W2008795411 cites W1999047723 @default.
• W2008795411 cites W2002040841 @default.
• W2008795411 cites W2002360937 @default.
• W2008795411 cites W2003307484 @default.
• W2008795411 cites W2005570145 @default.
• W2008795411 cites W2008123628 @default.
• W2008795411 cites W2008309860 @default.
• W2008795411 cites W2009544696 @default.
• W2008795411 cites W2010429702 @default.
• W2008795411 cites W2011405075 @default.
• W2008795411 cites W2011607421 @default.
• W2008795411 cites W2012756035 @default.
• W2008795411 cites W2013917042 @default.
• W2008795411 cites W2016665536 @default.
• W2008795411 cites W2017038113 @default.
• W2008795411 cites W2019085725 @default.
• W2008795411 cites W2021638685 @default.
• W2008795411 cites W2023807785 @default.
• W2008795411 cites W2030056942 @default.
• W2008795411 cites W2030264105 @default.
• W2008795411 cites W2030269444 @default.
• W2008795411 cites W2033041043 @default.
• W2008795411 cites W2033352933 @default.
• W2008795411 cites W2038001110 @default.
• W2008795411 cites W2043989787 @default.
• W2008795411 cites W2045422474 @default.
• W2008795411 cites W2046625748 @default.
• W2008795411 cites W2048252043 @default.
• W2008795411 cites W2051827538 @default.
• W2008795411 cites W2054223152 @default.
• W2008795411 cites W2056246338 @default.
• W2008795411 cites W2056453119 @default.
• W2008795411 cites W2058417598 @default.
• W2008795411 cites W2058821461 @default.
• W2008795411 cites W2058868266 @default.
• W2008795411 cites W2062374897 @default.
• W2008795411 cites W2063267366 @default.
• W2008795411 cites W2064463576 @default.
• W2008795411 cites W2066982884 @default.

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