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- W2008795929 abstract "The host-cell reactivation of V antigen production for irradiated adenovirus was examined in fibroblasts from 5 unrelated patients with Cockayne's syndrome (CS) and 2 CS heterozygotes. The fibroblast cultures were infected with either irradiated or non-irradiated adenovirus and subsequently examined for the presence of viral structural antigens using immunofluorescent staining. All CS-homozygous strains showed a reduced host-cell reactivation (HCR) of this viral function for both UV-and gamma-irradiated virus. For UV-irradiation of the virus, D37 values expressed as a percentage of that obtained on normal strains, ranged from 14 to 35%. For gamma-irradiation of the virus these values ranged from 61 to 80%. These results indicate some defect in the repair of both UV- and gamma-ray-induced DNA damage for CS. 1 CS-heterozygote strain tested also showed a reduced HCR for UV-irradiated adenovirus intermediate between that of the patient strain and normal, whereas another CS-heterozygote strain showed apparently normal HCR level." @default.
- W2008795929 created "2016-06-24" @default.
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- W2008795929 date "1982-03-01" @default.
- W2008795929 modified "2023-10-01" @default.
- W2008795929 title "A deficiency in the repair of UV and γ-ray damaged DNA in fibroblasts from Cockayne's syndrome" @default.
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- W2008795929 doi "https://doi.org/10.1016/0027-5107(82)90138-5" @default.
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