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- W2008803670 abstract "Beta-2-adrenergic substances can stimulate endogenous erythropoietin production, and thereby erythropoiesis (Fisher 1988, Krantz 1991). Consequently, it is possible that beta-2-stimulators, as indirect stimulators of erythropoiesis, may be used to increase aerobic performance in athletes. PURPOSE: To elucidate the effect of a high dose of inhalation of a beta-2-stimulator (salbutamol) on erythropoietin concentration and some indices of an increased erythropoiesis. METHODS: 15 healthy males, aged 20–30 years, participated in a double-blind cross-over study on the effect of salbutamol on erythropoletin concentration and hemoglobin concentration. The treatment period comprised inhalation of salbutamol, 0.8 mg four times daily for 2 weeks. RESULTS: Serum-erythropoletin was essentially unaltered after treatment with salbutamol, 9.5 ± 4.94 IU.L-1 (mean ± SD), as compared to both control situation, 9.2 ± 4.50 IU.L-1 (mean ± SD), and placebo treatment (9.7 ± 4.07 IU.L-1) (mean ± SD). The same pattern, no significant changes between control situation and treatment with salbutamol or placebo, also applies to hemoglobin concentration. CONCLUSION: It is not possible to increase erythropoietin concentration and thereby erytropoiesis by inhalation of high doses of the IOC approved beta-2-stimulator salbutamol for 2 weeks in healthy young males." @default.
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- W2008803670 date "2002-05-01" @default.
- W2008803670 modified "2023-09-26" @default.
- W2008803670 title "EFFECTS OF SALBUTAMOL ON ENDOGENOUS ERYTHROPOIETIN CONCENTRATION" @default.
- W2008803670 doi "https://doi.org/10.1097/00005768-200205001-00489" @default.
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