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• W2008804935 abstract "Our understanding of the functions of oxytocin in mammals has recently been challenged by findings in transgenic mice in which the oxytocin gene has been knocked out. Mammals generally have only two posterior pituitary nonapeptide genes, for oxytocin and vasopressin, while some marsupials do not express oxytocin but do express a closely related peptide, mesotocin, which acts at the oxytocin receptor (Acher et al. 1995). Birds have arginine vasotocin and mesotocin (Acher et al. 1995), while among other vertebrates a subclass of cartilaginous fishes evidently produces oxytocin (Michel et al. 1993). Mice homozygous for deletion of exon 1 of the oxytocin gene, containing the oxytocin nonapeptide sequence, were produced by homologous recombination in mouse embryonic stem cells. Offspring from matings of the heterozygotes were in the correct Mendelian frequency, indicating no lethal developmental defects in the homozygotes, which later showed normal sexual maturation, with both males and females showing sexual behaviour and normal fertility (Nishimori et al. 1996). Young and colleagues (1996) used gene targeting to generate a mouse with most of the first intron and the last two of the three exons of the oxytocin gene eliminated. The amount of oxytocin gene transcripts in the supraoptic and paraventricular nuclei of homozygotes was 1% of the wild-type level, with less than 0·4% of the wild-type content of oxytocin in the pituitary gland, and no oxytocin detectable in blood plasma by RIA. In both types of oxytocin gene disablement, the only evident defect was a complete failure of postpartum homozygotes to transfer milk to the suckling young, which consequently did not survive unless the mothers were treated with exogenous oxytocin. Thus parturition and maternal behaviour proceeded without oxytocin, although these processes were not studied in detail. These findings are surprising in view of the vast literature on a wide range of species suggesting important roles for oxytocin in regulating gonadal function, in expression of sexual behaviour, in parturition and initiation of maternal behaviour as well as in lactation. It is appropriate to consider whether the results from the oxytocin knockout mice arise from peculiarities in the roles of oxytocin in the mouse in comparison with other species, or indicate redundancy in the mechanisms in which oxytocin normally has an important role; apart that is, from the milk-ejection reflex in which there is no evident redundancy, at least in the mouse." @default.
• W2008804935 created "2016-06-24" @default.
• W2008804935 creator A5007971923 @default.
• W2008804935 creator A5047874096 @default.
• W2008804935 date "1998-06-01" @default.
• W2008804935 modified "2023-09-25" @default.
• W2008804935 title "Sex, parturition and motherhood without oxytocin?" @default.
• W2008804935 cites W112189089 @default.
• W2008804935 cites W126447681 @default.
• W2008804935 cites W1493670259 @default.
• W2008804935 cites W1501210689 @default.
• W2008804935 cites W1519557516 @default.
• W2008804935 cites W1532010673 @default.
• W2008804935 cites W1610981338 @default.
• W2008804935 cites W173069948 @default.
• W2008804935 cites W185732106 @default.
• W2008804935 cites W190466481 @default.
• W2008804935 cites W1918406217 @default.
• W2008804935 cites W1963731872 @default.
• W2008804935 cites W1963739271 @default.
• W2008804935 cites W1964255419 @default.
• W2008804935 cites W1964575355 @default.
• W2008804935 cites W1965806374 @default.
• W2008804935 cites W1967796224 @default.
• W2008804935 cites W1968993326 @default.
• W2008804935 cites W1969541181 @default.
• W2008804935 cites W1969746614 @default.
• W2008804935 cites W1972097431 @default.
• W2008804935 cites W1972414087 @default.
• W2008804935 cites W1973117823 @default.
• W2008804935 cites W1973836019 @default.
• W2008804935 cites W1975627625 @default.
• W2008804935 cites W1975645462 @default.
• W2008804935 cites W1975731777 @default.
• W2008804935 cites W1978833748 @default.
• W2008804935 cites W1979741250 @default.
• W2008804935 cites W1980943208 @default.
• W2008804935 cites W1981274379 @default.
• W2008804935 cites W1981615425 @default.
• W2008804935 cites W1983548585 @default.
• W2008804935 cites W1983657878 @default.
• W2008804935 cites W1985698173 @default.
• W2008804935 cites W1987264245 @default.
• W2008804935 cites W1988353832 @default.
• W2008804935 cites W1989283759 @default.
• W2008804935 cites W1989489055 @default.
• W2008804935 cites W1991503224 @default.
• W2008804935 cites W1991599848 @default.
• W2008804935 cites W1991614946 @default.
• W2008804935 cites W1994010754 @default.
• W2008804935 cites W1994624978 @default.
• W2008804935 cites W1995966782 @default.
• W2008804935 cites W1997442209 @default.
• W2008804935 cites W1999503138 @default.
• W2008804935 cites W2000399626 @default.
• W2008804935 cites W2001785728 @default.
• W2008804935 cites W2001920268 @default.
• W2008804935 cites W2001961421 @default.
• W2008804935 cites W2002759316 @default.
• W2008804935 cites W2004061821 @default.
• W2008804935 cites W2004386263 @default.
• W2008804935 cites W2005434501 @default.
• W2008804935 cites W2005681726 @default.
• W2008804935 cites W2006453448 @default.
• W2008804935 cites W2006636223 @default.
• W2008804935 cites W2007543186 @default.
• W2008804935 cites W2012548953 @default.
• W2008804935 cites W2013485356 @default.
• W2008804935 cites W2014726218 @default.
• W2008804935 cites W2015363208 @default.
• W2008804935 cites W2015844461 @default.
• W2008804935 cites W2016504297 @default.
• W2008804935 cites W2016940016 @default.
• W2008804935 cites W2017734995 @default.
• W2008804935 cites W2019094156 @default.
• W2008804935 cites W2019175624 @default.
• W2008804935 cites W2020089418 @default.
• W2008804935 cites W2020093363 @default.
• W2008804935 cites W2020388103 @default.
• W2008804935 cites W2020541190 @default.
• W2008804935 cites W2022265329 @default.
• W2008804935 cites W2022888607 @default.
• W2008804935 cites W2023145768 @default.
• W2008804935 cites W2023238302 @default.
• W2008804935 cites W2024968692 @default.
• W2008804935 cites W2027523671 @default.
• W2008804935 cites W2028245819 @default.
• W2008804935 cites W2029315800 @default.
• W2008804935 cites W2029560134 @default.
• W2008804935 cites W2030483557 @default.
• W2008804935 cites W2030988864 @default.
• W2008804935 cites W2031156296 @default.
• W2008804935 cites W2032388140 @default.
• W2008804935 cites W2034410522 @default.
• W2008804935 cites W2037364012 @default.
• W2008804935 cites W2037920771 @default.
• W2008804935 cites W2039701843 @default.
• W2008804935 cites W2040784339 @default.

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