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- W2008806520 abstract "Spiegelmers are structured mirror-image oligonucleotides that are designed to bind and inhibit pharmacologically relevant target molecules. The synthesis and purification of mirror-image oligonucleotides is comparable to the manufacturing of standard oligonucleotides that consist of naturally configured nucleotides. Due to the use of the non-natural L-nucleotides in Spiegelmers, these oligonucleotides show an exceptional biostability. Further, they also display a high physicochemical stability in solution. These properties make them interesting substances for drug development." @default.
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- W2008806520 date "2008-09-01" @default.
- W2008806520 modified "2023-10-16" @default.
- W2008806520 title "Physicochemical Stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for Therapeutic Applications" @default.
- W2008806520 doi "https://doi.org/10.1093/nass/nrn031" @default.
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