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• W2008821925 abstract "The initial treatment of T 1 esophageal squamous cell carcinoma ( SCC) is partly controversial due to the difficulties in accurate detection of metastatic lymph nodes by imaging and evaluation of treatment results. In this retrospective analysis, we investigated the efficacy and feasibility of chemoradiotherapy for T1N0-1M0 esophageal SCC. Concurrent chemoradiotherapy was applied to 12 patients with T 1 disease (T 1 N0-1 M0) evaluated according to UICC-TNM classification. Chemotherapy consisted of infusion of 5-fluorpuracil at 400 mg/m2/day on days 1 to 5 and 8 to 12, combined with 2-hour infusion of 40 mg/m2 cisplatin on days 1 and 8. Radiation dose of 30 Gy in 15 fractions of the mediastinum was applied during chemotherapy. A course schedule with 3 weeks of treatment and 2 weeks of break was applied twice, with a total radiation dose of 60 Gy. Based on CT scan, 3 patients had regional lymph node metastasis and 9 had no such metastasis. All 12 patients achieved complete response and the 3-year survival rate was 92%. Major toxicities were leukocytopenia (25%) and esophagitis (33%) . Minute local recurrence was found in 2 (17%) patients who subsequently underwent EMR, and no recurrence was noted more than two years after EMR. No patient underwent esophagectomy for local recurrence or lymph node metastasis. All patients had good performance status before and after chemoirradiation. Concurrent chemoradiotherapy is potentially curative for T1 esophageal SCC including N1 disease." @default.
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• W2008821925 date "2003-01-01" @default.
• W2008821925 modified "2023-09-23" @default.
• W2008821925 title "Concurrent Chemoradiotherapy as Initial Treatment for Patients with T1 Squamous Cell Carcinoma of The Esophagus : A Retrospective Analysis" @default.
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• W2008821925 doi "https://doi.org/10.15369/sujms1989.15.227" @default.
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