FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008837386> ?p ?o ?g. }

• W2008837386 endingPage "443" @default.
• W2008837386 startingPage "427" @default.
• W2008837386 abstract "Previous comparative studies have shown that long-lived animals have lower fatty acid double bond content in their mitochondrial membranes than short-lived ones. In order to ascertain whether this trait protects mitochondria by decreasing lipid and protein oxidation and oxygen radical generation, the double bond content of rat heart mitochondrial membranes was manipulated by chronic feeding with semi-purified AIN-93G diets rich in highly unsaturated (UNSAT) or saturated (SAT) oils. UNSAT rat heart mitochondria had significantly higher double bond content and lipid peroxidation than SAT mitochondria. They also showed increased levels of the markers of protein oxidative damage malondialdehyde-lysine, protein carbonyls, and N(e)-(carboxymethyl)lysine adducts. Basal rates of mitochondrial oxygen radical generation were not modified by the degree of fatty acid unsaturation, but the rates of H2O2 generation stimulated by antimycin A were higher in UNSAT than in SAT mitochondria. These results demonstrate that increasing the degree of fatty acid unsaturation of heart mitochondria increases oxidative damage to their lipids and proteins, and can also increase their rates of mitochondrial oxygen radical generation in situations in which the degree of reduction of Complex III is higher than normal. These observations strengthen the notion that the relatively low double bond content of the membranes of long-lived animals could have evolved to protect them from oxidative damage." @default.
• W2008837386 created "2016-06-24" @default.
• W2008837386 creator A5030906936 @default.
• W2008837386 creator A5050412857 @default.
• W2008837386 creator A5072345129 @default.
• W2008837386 creator A5078719319 @default.
• W2008837386 creator A5079424473 @default.
• W2008837386 date "2001-04-01" @default.
• W2008837386 modified "2023-10-15" @default.
• W2008837386 title "Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage" @default.
• W2008837386 cites W1264401779 @default.
• W2008837386 cites W1483212282 @default.
• W2008837386 cites W1515890089 @default.
• W2008837386 cites W1547195205 @default.
• W2008837386 cites W1565127991 @default.
• W2008837386 cites W1843398852 @default.
• W2008837386 cites W1879047861 @default.
• W2008837386 cites W1966658543 @default.
• W2008837386 cites W1982647833 @default.
• W2008837386 cites W1988380852 @default.
• W2008837386 cites W2000405107 @default.
• W2008837386 cites W2001495692 @default.
• W2008837386 cites W2005374900 @default.
• W2008837386 cites W2007579123 @default.
• W2008837386 cites W2009004590 @default.
• W2008837386 cites W2012953108 @default.
• W2008837386 cites W2015189666 @default.
• W2008837386 cites W2015528003 @default.
• W2008837386 cites W2020898911 @default.
• W2008837386 cites W2037246989 @default.
• W2008837386 cites W2040851417 @default.
• W2008837386 cites W2049126986 @default.
• W2008837386 cites W2050940363 @default.
• W2008837386 cites W2053054955 @default.
• W2008837386 cites W2063618152 @default.
• W2008837386 cites W2065012620 @default.
• W2008837386 cites W2068862678 @default.
• W2008837386 cites W2069921430 @default.
• W2008837386 cites W2073292071 @default.
• W2008837386 cites W2074622106 @default.
• W2008837386 cites W2100837269 @default.
• W2008837386 cites W2113144597 @default.
• W2008837386 cites W2113279188 @default.
• W2008837386 cites W2118935778 @default.
• W2008837386 cites W2120727649 @default.
• W2008837386 cites W2121926883 @default.
• W2008837386 cites W2406327877 @default.
• W2008837386 cites W323458356 @default.
• W2008837386 cites W835098822 @default.
• W2008837386 doi "https://doi.org/10.1016/s0047-6374(01)00214-7" @default.
• W2008837386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11240164" @default.
• W2008837386 hasPublicationYear "2001" @default.
• W2008837386 type Work @default.
• W2008837386 sameAs 2008837386 @default.
• W2008837386 citedByCount "51" @default.
• W2008837386 countsByYear W20088373862012 @default.
• W2008837386 countsByYear W20088373862013 @default.
• W2008837386 countsByYear W20088373862014 @default.
• W2008837386 countsByYear W20088373862015 @default.
• W2008837386 countsByYear W20088373862016 @default.
• W2008837386 countsByYear W20088373862017 @default.
• W2008837386 countsByYear W20088373862019 @default.
• W2008837386 countsByYear W20088373862020 @default.
• W2008837386 countsByYear W20088373862023 @default.
• W2008837386 crossrefType "journal-article" @default.
• W2008837386 hasAuthorship W2008837386A5030906936 @default.
• W2008837386 hasAuthorship W2008837386A5050412857 @default.
• W2008837386 hasAuthorship W2008837386A5072345129 @default.
• W2008837386 hasAuthorship W2008837386A5078719319 @default.
• W2008837386 hasAuthorship W2008837386A5079424473 @default.
• W2008837386 hasConcept C181199279 @default.
• W2008837386 hasConcept C185592680 @default.
• W2008837386 hasConcept C201268389 @default.
• W2008837386 hasConcept C2776151105 @default.
• W2008837386 hasConcept C2778401633 @default.
• W2008837386 hasConcept C2780795997 @default.
• W2008837386 hasConcept C2780829032 @default.
• W2008837386 hasConcept C28859421 @default.
• W2008837386 hasConcept C43617362 @default.
• W2008837386 hasConcept C543025807 @default.
• W2008837386 hasConcept C55493867 @default.
• W2008837386 hasConcept C57600042 @default.
• W2008837386 hasConcept C86803240 @default.
• W2008837386 hasConceptScore W2008837386C181199279 @default.
• W2008837386 hasConceptScore W2008837386C185592680 @default.
• W2008837386 hasConceptScore W2008837386C201268389 @default.
• W2008837386 hasConceptScore W2008837386C2776151105 @default.
• W2008837386 hasConceptScore W2008837386C2778401633 @default.
• W2008837386 hasConceptScore W2008837386C2780795997 @default.
• W2008837386 hasConceptScore W2008837386C2780829032 @default.
• W2008837386 hasConceptScore W2008837386C28859421 @default.
• W2008837386 hasConceptScore W2008837386C43617362 @default.
• W2008837386 hasConceptScore W2008837386C543025807 @default.
• W2008837386 hasConceptScore W2008837386C55493867 @default.
• W2008837386 hasConceptScore W2008837386C57600042 @default.
• W2008837386 hasConceptScore W2008837386C86803240 @default.
• W2008837386 hasIssue "4" @default.
• W2008837386 hasLocation W20088373861 @default.

• next