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- W2008848706 abstract "1 In 15 rats anaesthetized with ketamine, microiontophoretically applied acetylcholine (ACh) excited all 58 cells studied in the subthalamic nucleus (STN). 2 The ACh-evoked excitation was slow in onset and outlasted the ACh application. There was no sign of desensitization when the ACh application was prolonged or repeated. The excitation was prolonged by a concomitant application of physostigmine. 3 Acetyl-β-methyl choline and oxotremorine were effective cholinomimetics. Nicotine had no effect. 4 The ACh excitation was antagonized by atropine and scopolamine but not by mecamylamine. 5 It was concluded that STN ACh receptors are muscarinic in character. 6 Since large microiontophoretic applications of Mg2+ did not suppress ACh-evoked excitation, it is suggested that ACh acts postsynaptically. 7 The excitatory response of STN cells to striatal or pallidal stimulation was unaffected by atropine administered either microiontophoretically to single cells or intravenously (3 mg/kg) to the whole animal." @default.
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- W2008848706 date "1979-03-01" @default.
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- W2008848706 title "PHARMACOLOGICAL PROPERTIES OF ACETYLCHOLINE-INDUCED EXCITATION OF SUBTHALAMIC NUCLEUS NEURONES" @default.
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- W2008848706 doi "https://doi.org/10.1111/j.1476-5381.1979.tb07859.x" @default.
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