Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008857251> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2008857251 endingPage "2591" @default.
- W2008857251 startingPage "2591" @default.
- W2008857251 abstract "Cimetidine is an imidazole derivative, which acts as H2-receptor antagonist to inhibit gastric acid secretion and is thereby useful in the treatment of ulcers and other hyperacidity stomach disorders. This study sets out to provide simple, inexpensive and sensitive analytical techniques for the assay of cimetidine in tablet dosage forms using first derivative potentiometric and UV-spectrophotometric techniques, with a view to providing simple, sensitive and cost-effective analytical methods. Ten brands of cimetidine tablets were purchased from pharmacies in Yenagoa and Port Harcourt, Niger Delta region of Nigeria. The samples were assayed by Potentiometric and UV spectrophotometric methods after a Thin Layer Chromatographic (TLC) fingerprint. The potentiometric assay results of the samples ranged from 92-100% of stated amount for 70% of the samples. The coefficient of variation for In-between run, Intra-day run and accuracy of the UV spectrophotometric method was within 3%. The percentage purity of cimetidine from UV determination at 260 nm ranged from 86 - 97%, showing that 50% of the samples conformed to the stated standard – ie: contain 95- 105% of stated amount. The TLC fingerprints of the samples were similar in many respects, including R<sub>f</sub> values which ranged from 0.8 to 0.9 compared to the reference sample with R<sub>f</sub> value of 0.9. The results suggest that either of the two methods can be fine-tuned for assay of cimetidine in tablet formulations.Keywords: Potentiometry, ultraviolet (UV) spectrophotometry, analytical methods, cimetidine, Tablet Formulations, volumetric standard (VS)" @default.
- W2008857251 created "2016-06-24" @default.
- W2008857251 creator A5032998843 @default.
- W2008857251 creator A5037332859 @default.
- W2008857251 creator A5061970794 @default.
- W2008857251 date "2014-05-18" @default.
- W2008857251 modified "2023-10-05" @default.
- W2008857251 title "First derivative potentiometric and spectrophotometric determinations of cimetidine in tablets" @default.
- W2008857251 cites W1917856978 @default.
- W2008857251 cites W1966688562 @default.
- W2008857251 cites W1971937817 @default.
- W2008857251 cites W1986859935 @default.
- W2008857251 cites W2033842424 @default.
- W2008857251 cites W2037394238 @default.
- W2008857251 cites W2075309476 @default.
- W2008857251 cites W2077947585 @default.
- W2008857251 cites W2911537488 @default.
- W2008857251 doi "https://doi.org/10.4314/ijbcs.v7i6.33" @default.
- W2008857251 hasPublicationYear "2014" @default.
- W2008857251 type Work @default.
- W2008857251 sameAs 2008857251 @default.
- W2008857251 citedByCount "1" @default.
- W2008857251 countsByYear W20088572512015 @default.
- W2008857251 crossrefType "journal-article" @default.
- W2008857251 hasAuthorship W2008857251A5032998843 @default.
- W2008857251 hasAuthorship W2008857251A5037332859 @default.
- W2008857251 hasAuthorship W2008857251A5061970794 @default.
- W2008857251 hasBestOaLocation W20088572511 @default.
- W2008857251 hasConcept C124614425 @default.
- W2008857251 hasConcept C145148216 @default.
- W2008857251 hasConcept C153581625 @default.
- W2008857251 hasConcept C178790620 @default.
- W2008857251 hasConcept C185592680 @default.
- W2008857251 hasConcept C2780343419 @default.
- W2008857251 hasConcept C2780719153 @default.
- W2008857251 hasConcept C43617362 @default.
- W2008857251 hasConcept C71924100 @default.
- W2008857251 hasConcept C77281830 @default.
- W2008857251 hasConcept C89838059 @default.
- W2008857251 hasConcept C98274493 @default.
- W2008857251 hasConceptScore W2008857251C124614425 @default.
- W2008857251 hasConceptScore W2008857251C145148216 @default.
- W2008857251 hasConceptScore W2008857251C153581625 @default.
- W2008857251 hasConceptScore W2008857251C178790620 @default.
- W2008857251 hasConceptScore W2008857251C185592680 @default.
- W2008857251 hasConceptScore W2008857251C2780343419 @default.
- W2008857251 hasConceptScore W2008857251C2780719153 @default.
- W2008857251 hasConceptScore W2008857251C43617362 @default.
- W2008857251 hasConceptScore W2008857251C71924100 @default.
- W2008857251 hasConceptScore W2008857251C77281830 @default.
- W2008857251 hasConceptScore W2008857251C89838059 @default.
- W2008857251 hasConceptScore W2008857251C98274493 @default.
- W2008857251 hasIssue "6" @default.
- W2008857251 hasLocation W20088572511 @default.
- W2008857251 hasOpenAccess W2008857251 @default.
- W2008857251 hasPrimaryLocation W20088572511 @default.
- W2008857251 hasRelatedWork W167626745 @default.
- W2008857251 hasRelatedWork W1964688382 @default.
- W2008857251 hasRelatedWork W1998979254 @default.
- W2008857251 hasRelatedWork W2008857251 @default.
- W2008857251 hasRelatedWork W2062121918 @default.
- W2008857251 hasRelatedWork W2079664713 @default.
- W2008857251 hasRelatedWork W2083565842 @default.
- W2008857251 hasRelatedWork W2128457333 @default.
- W2008857251 hasRelatedWork W2398432106 @default.
- W2008857251 hasRelatedWork W4302468300 @default.
- W2008857251 hasVolume "7" @default.
- W2008857251 isParatext "false" @default.
- W2008857251 isRetracted "false" @default.
- W2008857251 magId "2008857251" @default.
- W2008857251 workType "article" @default.