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- W2008857963 abstract "INCREASED oxidative stress in the brain due to chronic ethanol consumption is known to result in a number of neurodegenerative changes. This study was designed to test whether dietary supplementation of grape polyphenols (GP) can offer protection to the neurodegenerative changes resulting from chronic ethanol consumption. Sprague-Dawley rats were fed a Leiber-DeCarli liquid diet with ethanol or isocaloric amount of maltose, and with or without GP for 2 months. Chronic ethanol caused significant decreases in synaptosomal Na, K-ATPase (20.5%) and dopamine uptake (22.8%) activities compared with pair-fed controls. Although GP alone did not alter activities of these membrane-bound proteins, GP supplementation was able to completely protect the decrease in synaptic protein function elicited by chronic ethanol consumption." @default.
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- W2008857963 title "Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration" @default.
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- W2008857963 doi "https://doi.org/10.1097/00001756-199901180-00018" @default.
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