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- W2008861966 abstract "The pharmacokinetics of lidocaine and bupivacaine and tri-deuteromethyl-labelled lidocaine and bupivacaine were investigated in healthy volunteers. The deuterium-labelled and the unlabelled form of the drug to be investigated were simultaneously infused in 10 min. Plasma concentrations were determined using a combination of capillary gas chromatography and mass fragmentography. Bi-exponential functions were fitted to the plasma concentration-time data. The mean distribution and elimination half-lives were 8.4±5.9 min and 96±26 min for lidocaine, 9.2±7·0 min and 98±27 min for deuterium-labelled lidocaine, 15.3±9·9 min and 111±32 min for bupivacaine, and 15.2 ± 10.9 min and 109±31 min for deuterium-labelled bupivacaine, respectively. The mean volumes of the central compartment and mean steady state volumes of distribution were: lidocaine 37±151 and 97±201, deuterium-labelled lidocaine 39±161 and 98±181, bupivacaine 27±111 and 66±231 and deuterium-labelled bupivacaine 28±121, and 65±221, respectively. The respective mean plasma clearances were 0.88±0181 min−1, 0.87±0.181 min−1, 0.61±0.151 min−1, and 0.62±0.171 min−1. The results of the study indicate that substitution of a deuterated methyl group does not alter the pharmacokinetics of lidocaine and bupivacaine in healthy subjects." @default.
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- W2008861966 date "1988-01-01" @default.
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- W2008861966 title "Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: A study in healthy volunteers" @default.
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- W2008861966 doi "https://doi.org/10.1002/bod.2510090109" @default.
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