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- W2008881783 abstract "We studied a 68-year-old man who died after 13 years of progressive dementia, rigidity, bradykinesia, mild tremor, stooped posture, slow and shuffling gait, dystonia, blepharospasm, apraxia of eyelid opening, anarthria, aphonia, and incontinence. At autopsy, he had generalized brain atrophy with large deposits of iron pigment in the globus pallidus, caudate, and substantia nigra. Axonal spheroids were found in the globus pallidus, substantia nigra, medulla, and spinal cord. The neurochemical analysis of the brain revealed marked loss of dopamine in the nigral-striatal areas, with relative preservation of dopamine in the limbic areas. This is the oldest case of familial Hallervorden-Spatz disease reported and the first with neurochemical analysis of the brain." @default.
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- W2008881783 date "1985-02-01" @default.
- W2008881783 modified "2023-10-04" @default.
- W2008881783 title "Late-onset Hallervorden-Spatz disease presenting as familial parkinsonism" @default.
- W2008881783 doi "https://doi.org/10.1212/wnl.35.2.227" @default.
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