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- W2008885504 abstract "We conducted a retrospective chart review to examine the pharmacokinetic interaction between desipramine and the stimulants methylphenidate and dexedrine using routinely monitored desipramine serum concentrations in children receiving desipramine either alone or with a stimulant. Subjects were 142 children and adolescents (age 6–17 yrs; 113 taking desipramine, 29 taking desipramine-stimulants) in whom 401 dose- and weight-normalized serum concentrations were evaluated (333 desipramine, 68 desipramine-stimulants). Desipramine pharmacokinetic parameters were similar for both groups, including mean weight-corrected dose (3.66 ± 1.36 mg/kg, desipramine; 3.66 ± 1.09 mg/kg, desipramine-stimulants; p=0.97), weight- and dose-normalized serum concentrations (47.26 ± 39.26 [μg/L]/[mg/kg], desipramine, 39.02 ± 19.92 [μg/L]/[mg/kg], desipramine-stimulants; p=0.09), and clearance (0.690 ± 0.913 [L/kg]/hr, desipramine; 0.613 ± 0.514 [L/kg]/hr, desipramine-stimulants; p=0.499). When stratified by age, gender, and type of stimulant, no difference was detected (p>0.05) between groups. Our findings indicate the absence of a clinically significant interaction between desipramine and stimulants." @default.
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- W2008885504 date "1999-06-01" @default.
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- W2008885504 title "Absence of Effect of Stimulants on the Pharmacokinetics of Desipramine in Children" @default.
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- W2008885504 doi "https://doi.org/10.1592/phco.19.9.746.31539" @default.
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