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• W2008885936 abstract "Left ventricular function during brief (10 minutes) and prolonged (2 hours) upright bicycle exercise was studied in nine young men. Left ventricular ejection fraction and volumes and cardiac output were measured by radionuclide angiocardiography at rest, during submaximal effort at 10 minutes of the prolonged exercise period and during maximal effort at the conclusion of both exercise periods. The cardiac Output Increased from 6.2 ± 1.6 at rest to 17.4 ± 2.9 liters/min during submaximal effort at 10 minutes as a result of a 93 percent increase in heart rate (70 ± 13 to 135 ± 12 beats/min, p <0.001) and a 45 percent increase in stroke volume (89 ± 13 to 129 ± 19 ml, p <0.001). Both an increased ejection fraction (63 ± 6 versus 79 ± 6 percent, p <0.001) and. a larger end-diastolic volume (144 ± 24 versus 164 ± 23 ml, p <0.005) contributed to the increase in stroke volume. The subjects achieved the same heart rate of 180 beats/min during maximal effort at the conclusion of both exercise periods. However, cardiac output was 15 percent greater during the brief exercise period than during the prolonged exercise period (26.9± 3.1 versus 23.4 ± 3.7 liters/min, p <0.001) primarily due to a larger end-diastolic volume (179 ± 22 versus 162 ± 24 ml, p <0.01), although the ejection fraction was also slightly Increased (84 ± 5 versus 81 ± 5 percent, p <0.05). All subjects experienced a significant weight loss and an increase in hematocrtt during the prolonged exercise period. These findings suggest that fluid loss during prolonged exercise limited maximal cardiac performance. The results of this study indicate that the Starling mechanism is operative during upright exercise in man." @default.
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• W2008885936 date "1980-06-01" @default.
• W2008885936 modified "2023-10-16" @default.
• W2008885936 title "Effect of brief and prolonged exercise on left ventricular function" @default.
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• W2008885936 doi "https://doi.org/10.1016/0002-9149(80)90473-7" @default.
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