FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008886919> ?p ?o ?g. }

• W2008886919 endingPage "17133" @default.
• W2008886919 startingPage "17129" @default.
• W2008886919 abstract "The peroxisome proliferator-activated receptor (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis. This paper presents a detailed dynamics study of PPAR-gamma and its binding to the agonist rosiglitazone using both polarized and unpolarized force fields. The numerical result revealed the critical role of protein polarization in stabilizing the activation function-2 (AF-2) in ligand binding to PPAR-gamma and a helix structure (helix-2'). Specifically when nonpolarized force field is used, a critical H-bond in PPAR-gamma binding is broken, which caused AF-2 to adopt random structures. In addition, helix-2' is partially denatured during the MD simulation, due to the breaking of a backbone hydrogen bond. In contrast, when polarized force field is employed in MD simulation, the PPAR-gamma ligand binding structure is stabilized and the local structure of helix-2' remains folded, both being in excellent agreement with experimental observations. The current result demonstrates the importance of electronic polarization of protein in stabilizing hydrogen bonding, which is critical to preserving the native structure of local helices and protein-ligand binding in PPAR-gamma." @default.
• W2008886919 created "2016-06-24" @default.
• W2008886919 creator A5066410016 @default.
• W2008886919 creator A5077039256 @default.
• W2008886919 date "2008-11-13" @default.
• W2008886919 modified "2023-09-26" @default.
• W2008886919 title "Protein Polarization Is Critical to Stabilizing AF-2 and Helix-2′ Domains in Ligand Binding to PPAR-γ" @default.
• W2008886919 cites W1723187988 @default.
• W2008886919 cites W1983598802 @default.
• W2008886919 cites W2004734612 @default.
• W2008886919 cites W2008708467 @default.
• W2008886919 cites W2014889017 @default.
• W2008886919 cites W2024299353 @default.
• W2008886919 cites W2045999118 @default.
• W2008886919 cites W2046886830 @default.
• W2008886919 cites W2047591801 @default.
• W2008886919 cites W2069123478 @default.
• W2008886919 cites W2077633266 @default.
• W2008886919 cites W2083319939 @default.
• W2008886919 cites W2094558395 @default.
• W2008886919 cites W2097511872 @default.
• W2008886919 cites W2107021176 @default.
• W2008886919 cites W2107454494 @default.
• W2008886919 cites W2107752044 @default.
• W2008886919 cites W2109539263 @default.
• W2008886919 cites W2113456624 @default.
• W2008886919 cites W2123643321 @default.
• W2008886919 cites W2144288821 @default.
• W2008886919 cites W2147993766 @default.
• W2008886919 cites W2156408001 @default.
• W2008886919 cites W2161337867 @default.
• W2008886919 cites W2170831952 @default.
• W2008886919 cites W2172256092 @default.
• W2008886919 cites W2406539631 @default.
• W2008886919 cites W4296989265 @default.
• W2008886919 cites W59002756 @default.
• W2008886919 doi "https://doi.org/10.1021/ja807374x" @default.
• W2008886919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19007119" @default.
• W2008886919 hasPublicationYear "2008" @default.
• W2008886919 type Work @default.
• W2008886919 sameAs 2008886919 @default.
• W2008886919 citedByCount "72" @default.
• W2008886919 countsByYear W20088869192012 @default.
• W2008886919 countsByYear W20088869192013 @default.
• W2008886919 countsByYear W20088869192014 @default.
• W2008886919 countsByYear W20088869192015 @default.
• W2008886919 countsByYear W20088869192016 @default.
• W2008886919 countsByYear W20088869192017 @default.
• W2008886919 countsByYear W20088869192018 @default.
• W2008886919 countsByYear W20088869192019 @default.
• W2008886919 countsByYear W20088869192020 @default.
• W2008886919 countsByYear W20088869192021 @default.
• W2008886919 countsByYear W20088869192022 @default.
• W2008886919 crossrefType "journal-article" @default.
• W2008886919 hasAuthorship W2008886919A5066410016 @default.
• W2008886919 hasAuthorship W2008886919A5077039256 @default.
• W2008886919 hasConcept C112887158 @default.
• W2008886919 hasConcept C116569031 @default.
• W2008886919 hasConcept C12554922 @default.
• W2008886919 hasConcept C170493617 @default.
• W2008886919 hasConcept C178790620 @default.
• W2008886919 hasConcept C185592680 @default.
• W2008886919 hasConcept C187345961 @default.
• W2008886919 hasConcept C18903297 @default.
• W2008886919 hasConcept C2778530040 @default.
• W2008886919 hasConcept C2778938600 @default.
• W2008886919 hasConcept C2779965526 @default.
• W2008886919 hasConcept C32909587 @default.
• W2008886919 hasConcept C47701112 @default.
• W2008886919 hasConcept C55493867 @default.
• W2008886919 hasConcept C71240020 @default.
• W2008886919 hasConcept C8010536 @default.
• W2008886919 hasConcept C86803240 @default.
• W2008886919 hasConceptScore W2008886919C112887158 @default.
• W2008886919 hasConceptScore W2008886919C116569031 @default.
• W2008886919 hasConceptScore W2008886919C12554922 @default.
• W2008886919 hasConceptScore W2008886919C170493617 @default.
• W2008886919 hasConceptScore W2008886919C178790620 @default.
• W2008886919 hasConceptScore W2008886919C185592680 @default.
• W2008886919 hasConceptScore W2008886919C187345961 @default.
• W2008886919 hasConceptScore W2008886919C18903297 @default.
• W2008886919 hasConceptScore W2008886919C2778530040 @default.
• W2008886919 hasConceptScore W2008886919C2778938600 @default.
• W2008886919 hasConceptScore W2008886919C2779965526 @default.
• W2008886919 hasConceptScore W2008886919C32909587 @default.
• W2008886919 hasConceptScore W2008886919C47701112 @default.
• W2008886919 hasConceptScore W2008886919C55493867 @default.
• W2008886919 hasConceptScore W2008886919C71240020 @default.
• W2008886919 hasConceptScore W2008886919C8010536 @default.
• W2008886919 hasConceptScore W2008886919C86803240 @default.
• W2008886919 hasIssue "50" @default.
• W2008886919 hasLocation W20088869191 @default.
• W2008886919 hasLocation W20088869192 @default.
• W2008886919 hasOpenAccess W2008886919 @default.
• W2008886919 hasPrimaryLocation W20088869191 @default.
• W2008886919 hasRelatedWork W1980377213 @default.
• W2008886919 hasRelatedWork W2000749144 @default.
• W2008886919 hasRelatedWork W2035164663 @default.

• next