Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008889685> ?p ?o ?g. }
- W2008889685 endingPage "128" @default.
- W2008889685 startingPage "122" @default.
- W2008889685 abstract "Regimen-related toxicities remain a priority concern within the field of supportive care in cancer. Despite this, many forms of toxicity are under reported and consequently poorly characterised. Although there have been significant improvements in our understanding of regimen-related toxicities, symptom management continues to occur independently raising concerns such as drug interactions and the tendency to emphasise management of a single symptom at the expense of others. This review focuses on two important toxicities induced by chemotherapy; neuropathy/pain and gastrointestinal toxicity, introducing the Toll-like receptor (TLR) 4 pathway as a common component of their pathobiology. Given the global observation of toxicity clusters, identification of a common initiating factor provides an excellent opportunity to simultaneously target multiple side effects of anticancer treatment. Furthermore, identification of common biological underpinnings could perhaps reduce polypharmacy and have pharmacoeconomic benefits." @default.
- W2008889685 created "2016-06-24" @default.
- W2008889685 creator A5015659735 @default.
- W2008889685 creator A5028274750 @default.
- W2008889685 creator A5041862478 @default.
- W2008889685 creator A5051753017 @default.
- W2008889685 creator A5052756021 @default.
- W2008889685 creator A5068340612 @default.
- W2008889685 creator A5079301265 @default.
- W2008889685 date "2015-02-01" @default.
- W2008889685 modified "2023-09-30" @default.
- W2008889685 title "Toll-like receptor 4 signaling: A common biological mechanism of regimen-related toxicities" @default.
- W2008889685 cites W140248828 @default.
- W2008889685 cites W1555940993 @default.
- W2008889685 cites W1579021252 @default.
- W2008889685 cites W1594425991 @default.
- W2008889685 cites W1607354731 @default.
- W2008889685 cites W1857364306 @default.
- W2008889685 cites W1963663378 @default.
- W2008889685 cites W1967912747 @default.
- W2008889685 cites W1968402792 @default.
- W2008889685 cites W1968680840 @default.
- W2008889685 cites W1971063834 @default.
- W2008889685 cites W1971867342 @default.
- W2008889685 cites W1973190490 @default.
- W2008889685 cites W1976010325 @default.
- W2008889685 cites W1976971060 @default.
- W2008889685 cites W1977663897 @default.
- W2008889685 cites W1979068418 @default.
- W2008889685 cites W1979960106 @default.
- W2008889685 cites W1984232954 @default.
- W2008889685 cites W1986707934 @default.
- W2008889685 cites W1995304737 @default.
- W2008889685 cites W1997125320 @default.
- W2008889685 cites W2001739398 @default.
- W2008889685 cites W2003103971 @default.
- W2008889685 cites W2003926510 @default.
- W2008889685 cites W2004657695 @default.
- W2008889685 cites W2005330710 @default.
- W2008889685 cites W2008296200 @default.
- W2008889685 cites W2010055058 @default.
- W2008889685 cites W2011848992 @default.
- W2008889685 cites W2012899659 @default.
- W2008889685 cites W2013100814 @default.
- W2008889685 cites W2016052090 @default.
- W2008889685 cites W2018461309 @default.
- W2008889685 cites W2019863741 @default.
- W2008889685 cites W2020636978 @default.
- W2008889685 cites W2022874516 @default.
- W2008889685 cites W2023505415 @default.
- W2008889685 cites W2027923776 @default.
- W2008889685 cites W2029736480 @default.
- W2008889685 cites W2036436547 @default.
- W2008889685 cites W2038064303 @default.
- W2008889685 cites W2045098547 @default.
- W2008889685 cites W2046023535 @default.
- W2008889685 cites W2046876037 @default.
- W2008889685 cites W2048415064 @default.
- W2008889685 cites W2049455810 @default.
- W2008889685 cites W2056804370 @default.
- W2008889685 cites W2056826548 @default.
- W2008889685 cites W2057913943 @default.
- W2008889685 cites W2062662142 @default.
- W2008889685 cites W2063153146 @default.
- W2008889685 cites W2065442814 @default.
- W2008889685 cites W2070158337 @default.
- W2008889685 cites W2075782105 @default.
- W2008889685 cites W2076087096 @default.
- W2008889685 cites W2082980766 @default.
- W2008889685 cites W2083797385 @default.
- W2008889685 cites W2091080691 @default.
- W2008889685 cites W2091858438 @default.
- W2008889685 cites W2092408112 @default.
- W2008889685 cites W2097809605 @default.
- W2008889685 cites W2098039671 @default.
- W2008889685 cites W2099039895 @default.
- W2008889685 cites W2103076324 @default.
- W2008889685 cites W2103801183 @default.
- W2008889685 cites W2107865650 @default.
- W2008889685 cites W2108163830 @default.
- W2008889685 cites W2115185894 @default.
- W2008889685 cites W2120003285 @default.
- W2008889685 cites W2121347099 @default.
- W2008889685 cites W2122828560 @default.
- W2008889685 cites W2128631317 @default.
- W2008889685 cites W2130681302 @default.
- W2008889685 cites W2131763400 @default.
- W2008889685 cites W2132929849 @default.
- W2008889685 cites W2135050229 @default.
- W2008889685 cites W2143352606 @default.
- W2008889685 cites W2149426628 @default.
- W2008889685 cites W2150594596 @default.
- W2008889685 cites W2151866033 @default.
- W2008889685 cites W2153616752 @default.
- W2008889685 cites W2155058651 @default.
- W2008889685 cites W2157282220 @default.
- W2008889685 cites W2157339124 @default.
- W2008889685 doi "https://doi.org/10.1016/j.ctrv.2014.11.005" @default.