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• W2008935385 abstract "Morphine activates μ-opioid receptors (MORs) without promoting their rapid endocytosis in a number of cell types. A previous study suggested that morphine can drive rapid redistribution of MORs in the nucleus accumbens, but it was not possible in this in vivo study to identify a specific membrane trafficking pathway affected by morphine, to exclude possible indirect actions of morphine via opiate-regulated neural circuitry, or to define the mechanism of this morphine-dependent regulation. In the present study, we addressed these questions using dissociated primary cultures of rat striatal neurons as a model system. Morphine promoted a rapid redistribution of both endogenous and recombinant MORs within 30 min after drug addition to the culture medium. This effect was mediated by rapid endocytosis and occurred in a cell-autonomous manner, as indicated by its detection in cells plated at low density and in cultures in which depolarization was blocked by tetrodotoxin. Morphine-induced endocytosis of MORs was quantitatively similar to that induced by the enkephalin analog d -Ala 2 - N -Me-Phe 4 -Glycol 5 -enkephalin, and endocytosis induced by both ligands was inhibited by a dominant-negative mutant version of arrestin-3 (β-arrestin-2). These results extend previous in vivo results and indicate that morphine is indeed capable of driving rapid endocytosis of μ-opioid receptors in an important subset of opiate-responsive CNS neurons. They also suggest a cellular mechanism by which β-arrestins may modulate the physiological effects of morphine in vivo ." @default.
• W2008935385 created "2016-06-24" @default.
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• W2008935385 date "2005-08-24" @default.
• W2008935385 modified "2023-10-18" @default.
• W2008935385 title "Morphine Promotes Rapid, Arrestin-Dependent Endocytosis of μ-Opioid Receptors in Striatal Neurons" @default.
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• W2008935385 doi "https://doi.org/10.1523/jneurosci.5045-04.2005" @default.
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