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• W2008946188 abstract "Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1 alpha transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1 alpha under non-hypoxic conditions but inhibits hypoxia-induced HIF-1 alpha expression." @default.
• W2008946188 created "2016-06-24" @default.
• W2008946188 creator A5051276665 @default.
• W2008946188 date "2001-04-01" @default.
• W2008946188 modified "2023-10-16" @default.
• W2008946188 title "HIF-1 and mechanisms of hypoxia sensing" @default.
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• W2008946188 doi "https://doi.org/10.1016/s0955-0674(00)00194-0" @default.
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