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- W2008949582 abstract "Multiple studies have demonstrated abnormalities of rheumatoid arthritis (RA)–related autoantibodies and biomarkers of inflammation prior to the presence of the signs and symptoms of inflammatory arthritis (1–18). Many of these studies were performed using retrospectively assembled samples from subjects who fortuitously had biologic specimens available from before their diagnosis of RA. Therefore, our understanding of the precise temporal relationship between biomarker abnormalities and the onset of the signs and symptoms of inflammatory arthritis is limited. However, despite these limitations, overall these studies have had a profound impact on the understanding of the early development of RA. Furthermore, these studies, in conjunction with studies that have established genetic risk factors for RA (such as the shared epitope [19]), support the concept that RA development occurs in several phases, as depicted in Figure 1." @default.
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- W2008949582 date "2012-05-25" @default.
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- W2008949582 title "Learning about the natural history of rheumatoid arthritis development through prospective study of subjects at high risk of rheumatoid arthritis-related autoimmunity" @default.
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- W2008949582 doi "https://doi.org/10.1002/art.34445" @default.
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