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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008952010> ?p ?o ?g. }

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• W2008952010 abstract "Gene expression noise varies with genomic position and is a driving force in the evolution of chromosome organization. Nevertheless, position effects remain poorly characterized. Here, we present a systematic analysis of chromosomal position effects by characterizing single-cell gene expression from euchromatic positions spanning the length of a eukaryotic chromosome. We demonstrate that position affects gene expression by modulating the size of transcriptional bursts, rather than their frequency, and that the histone deacetylase Sir2 plays a role in this process across the chromosome." @default.
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• W2008952010 date "2011-05-01" @default.
• W2008952010 modified "2023-09-28" @default.
• W2008952010 title "Chromosomal Position Effects Are Linked to Sir2-Mediated Variation in Transcriptional Burst Size" @default.
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• W2008952010 doi "https://doi.org/10.1016/j.bpj.2011.04.021" @default.
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