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• W2008959044 abstract "Background and Objective Epithelial cells are recognized as the first line of defense against bacterial infection and environmental harmful stimuli such as cigarette smoke ( CS ). Although previous studies explored the effects of nicotine on host cells, mechanisms by which CS affects cellular functions remain uncertain. The present study investigated the effects of CS condensate ( CSC ) on in vitro wound closure of gingival epithelial cells and their potential interactions with a major periodontal pathogen, P orphyromonas gingivalis . Material and Methods Human gingival epithelial cells (Ca9‐22) were treated with CSC for 24 h. Cell proliferation was determined using a WST ‐1 assay. Cell migration was assessed using a wound closure model. The expression of integrins was analyzed by confocal scanning laser microscopy and real‐time PCR . Intracellular invasion of P . gingivalis was evaluated by confocal scanning laser microscopy and an antibiotic protection assay. Results Low concentrations (1–10 μg/mL) of CSC showed no significant effect on cell proliferation. CSC demonstrated dual effects on epithelial wound closure of Ca9‐22 cells: high concentrations (i.e. 250 μg/mL) significantly inhibited the wound closure whereas low concentrations (i.e. 10 μg/mL) promoted it ( p < 0.01). CSC induced distinct changes in cytoskeleton. When CSC ‐exposed cells were infected with P . gingivalis for 2 h, a significant inhibition of wound closure was observed concurrent with a decrease in integrin α3 expression near the wound area. A significantly increased P . gingivalis invasion into Ca9‐22 was observed when exposed to low concentrations of CSC . Conclusion Low concentrations of CSC increased invasion of human gingival epithelial cells by P . gingivalis and induced changes in cytoskeleton and integrin expression, thereby modulating the cell migration." @default.
• W2008959044 created "2016-06-24" @default.
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• W2008959044 date "2014-09-05" @default.
• W2008959044 modified "2023-10-16" @default.
• W2008959044 title "Cigarette smoke condensate modulates migration of human gingival epithelial cells and their interactions with <i>Porphyromonas gingivalis</i>" @default.
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• W2008959044 doi "https://doi.org/10.1111/jre.12222" @default.
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