FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008977445> ?p ?o ?g. }

• W2008977445 endingPage "250" @default.
• W2008977445 startingPage "241" @default.
• W2008977445 abstract "C3 deficiency is a rare disorder that leads to recurrent pyogenic infections. Here we describe a previously healthy 18 y/o Caucasian male with severe meningococcal disease. Total hemolytic activity was zero secondary to an undetectable C3. The C3 gene was normal by sequencing. Mixing the patient's serum with normal human serum led to C3 consumption. An IgG autoantibody in the patient's serum was identified that stabilized the classical pathway C3 and C5 convertases, thus preventing decay of these enzyme complexes. This autoantibody is an example of a C4 nephritic factor, with an additional feature of stabilizing the C5 convertase. Previous patients with C4 nephritic factor had membranoproliferative glomerulonephritis. Two years after presentation, this patient's C3 remains undetectable with no evidence of renal disease. We revisit the role of autoantibodies to classical pathway convertases in disease, review the literature on C4-NeF and comment on its detection in the clinical laboratory." @default.
• W2008977445 created "2016-06-24" @default.
• W2008977445 creator A5008491017 @default.
• W2008977445 creator A5020658294 @default.
• W2008977445 creator A5030586479 @default.
• W2008977445 creator A5035054224 @default.
• W2008977445 creator A5068388146 @default.
• W2008977445 creator A5084704773 @default.
• W2008977445 date "2012-12-01" @default.
• W2008977445 modified "2023-10-18" @default.
• W2008977445 title "Autoantibody stabilization of the classical pathway C3 convertase leading to C3 deficiency and Neisserial sepsis: C4 nephritic factor revisited" @default.
• W2008977445 cites W121687570 @default.
• W2008977445 cites W1925941276 @default.
• W2008977445 cites W1963906871 @default.
• W2008977445 cites W1971659350 @default.
• W2008977445 cites W1979443248 @default.
• W2008977445 cites W1990643927 @default.
• W2008977445 cites W1998762189 @default.
• W2008977445 cites W2022255109 @default.
• W2008977445 cites W2029994821 @default.
• W2008977445 cites W2042425014 @default.
• W2008977445 cites W2047310221 @default.
• W2008977445 cites W2091933198 @default.
• W2008977445 cites W2104199760 @default.
• W2008977445 cites W2169637270 @default.
• W2008977445 cites W315197452 @default.
• W2008977445 cites W4230935285 @default.
• W2008977445 cites W4313315114 @default.
• W2008977445 cites W52122782 @default.
• W2008977445 cites W2048698291 @default.
• W2008977445 doi "https://doi.org/10.1016/j.clim.2012.09.007" @default.
• W2008977445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3501611" @default.
• W2008977445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23117396" @default.
• W2008977445 hasPublicationYear "2012" @default.
• W2008977445 type Work @default.
• W2008977445 sameAs 2008977445 @default.
• W2008977445 citedByCount "27" @default.
• W2008977445 countsByYear W20089774452013 @default.
• W2008977445 countsByYear W20089774452014 @default.
• W2008977445 countsByYear W20089774452015 @default.
• W2008977445 countsByYear W20089774452016 @default.
• W2008977445 countsByYear W20089774452017 @default.
• W2008977445 countsByYear W20089774452019 @default.
• W2008977445 countsByYear W20089774452020 @default.
• W2008977445 countsByYear W20089774452021 @default.
• W2008977445 countsByYear W20089774452022 @default.
• W2008977445 countsByYear W20089774452023 @default.
• W2008977445 crossrefType "journal-article" @default.
• W2008977445 hasAuthorship W2008977445A5008491017 @default.
• W2008977445 hasAuthorship W2008977445A5020658294 @default.
• W2008977445 hasAuthorship W2008977445A5030586479 @default.
• W2008977445 hasAuthorship W2008977445A5035054224 @default.
• W2008977445 hasAuthorship W2008977445A5068388146 @default.
• W2008977445 hasAuthorship W2008977445A5084704773 @default.
• W2008977445 hasBestOaLocation W20089774452 @default.
• W2008977445 hasConcept C111684460 @default.
• W2008977445 hasConcept C126322002 @default.
• W2008977445 hasConcept C159654299 @default.
• W2008977445 hasConcept C163764329 @default.
• W2008977445 hasConcept C171279029 @default.
• W2008977445 hasConcept C179369057 @default.
• W2008977445 hasConcept C182629451 @default.
• W2008977445 hasConcept C189446657 @default.
• W2008977445 hasConcept C203014093 @default.
• W2008977445 hasConcept C2778384902 @default.
• W2008977445 hasConcept C2780091579 @default.
• W2008977445 hasConcept C2780368995 @default.
• W2008977445 hasConcept C2781036514 @default.
• W2008977445 hasConcept C71924100 @default.
• W2008977445 hasConcept C9478725 @default.
• W2008977445 hasConceptScore W2008977445C111684460 @default.
• W2008977445 hasConceptScore W2008977445C126322002 @default.
• W2008977445 hasConceptScore W2008977445C159654299 @default.
• W2008977445 hasConceptScore W2008977445C163764329 @default.
• W2008977445 hasConceptScore W2008977445C171279029 @default.
• W2008977445 hasConceptScore W2008977445C179369057 @default.
• W2008977445 hasConceptScore W2008977445C182629451 @default.
• W2008977445 hasConceptScore W2008977445C189446657 @default.
• W2008977445 hasConceptScore W2008977445C203014093 @default.
• W2008977445 hasConceptScore W2008977445C2778384902 @default.
• W2008977445 hasConceptScore W2008977445C2780091579 @default.
• W2008977445 hasConceptScore W2008977445C2780368995 @default.
• W2008977445 hasConceptScore W2008977445C2781036514 @default.
• W2008977445 hasConceptScore W2008977445C71924100 @default.
• W2008977445 hasConceptScore W2008977445C9478725 @default.
• W2008977445 hasIssue "3" @default.
• W2008977445 hasLocation W20089774451 @default.
• W2008977445 hasLocation W20089774452 @default.
• W2008977445 hasLocation W20089774453 @default.
• W2008977445 hasLocation W20089774454 @default.
• W2008977445 hasOpenAccess W2008977445 @default.
• W2008977445 hasPrimaryLocation W20089774451 @default.
• W2008977445 hasRelatedWork W1970592101 @default.
• W2008977445 hasRelatedWork W1973996890 @default.
• W2008977445 hasRelatedWork W1980344266 @default.
• W2008977445 hasRelatedWork W2040189142 @default.
• W2008977445 hasRelatedWork W2134800117 @default.
• W2008977445 hasRelatedWork W2346482252 @default.

• next