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- W2008977549 abstract "The bradycardia-inducing effects of clonidine were examined in anesthetized or spinal rats by injecting the drug intracisternally (i. c.) or intravenously (i. v.). Clonidine (1-25μg i. c.) caused a bradycardia dose-dependently in anesthetized rats. The bradycardia in response to clonidine (5 μg i. e.) was Sig-nificantly reduced after a treatment with phentolamine (100 μg i. c.), but not influenced with atropine (1 mg i. v.) or sectioning bilateral cervical vagal nerves. In spinal rats, an acceleration in heart rate by electrical stimulation of cervical sympathetic nerves was frequency-dependent and that due to desmethylimipramine (DMI) was dose-dependent. Clonidine (30 μg i. v.) significantly inhibited the acceleration induced by electrical stimulations only at a low frequency (0.3-3 Hz) or DMI (0.3 mg i.v.). This inhibition by clonidine was antagonized by phentolamine (5 mg i. v.). Clonidine (30 μg i. v.) did not significantly influence the acceleration in heart rate of spinal rats induced by norepinephrine (1 μg i. v.), tyramine (100μg i. v.) or 1, 1-dimethyl-4-phenylpiperazinium (DMPP, 50 μg ix.). Therefore, it is suggested that clonidine causes a bradycardia by stimulating both peripheral and central α-adrenoceptors, the sympathetic trunk is the main pathway, and that the peripheral mechanism for elonidine-induced bradycardia is different from the action of guanethidine or hexamethonium on a release of catecholamines from the cardiac nerve terminals." @default.
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- W2008977549 title "Peripherally and Centrally Mediated Bradycardiac Effects of Clonidine in Anesthetized or Spinal Rats" @default.
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- W2008977549 doi "https://doi.org/10.1620/tjem.119.283" @default.
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