FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008980341> ?p ?o ?g. }

• W2008980341 endingPage "e91" @default.
• W2008980341 startingPage "e91" @default.
• W2008980341 abstract "The overall effect of brain zinc (Zn(2+)) in the progression and development of Alzheimer's disease (AD) is still not completely understood. Although an excess of Zn(2+) can exacerbate the pathological features of AD, a deficit of Zn(2+) intake has also been shown to increase the volume of amyloid plaques in AD transgenic mice. In this study, we investigated the effect of dietary Zn(2+) supplementation (30 p.p.m.) in a transgenic mouse model of AD, the 3xTg-AD, that expresses both β amyloid (Aβ)- and tau-dependent pathology. We found that Zn(2+) supplementation greatly delays hippocampal-dependent memory deficits and strongly reduces both Aβ and tau pathology in the hippocampus. We also evaluated signs of mitochondrial dysfunction and found that Zn(2+) supplementation prevents the age-dependent respiratory deficits we observed in untreated 3xTg-AD mice. Finally, we found that Zn(2+) supplementation greatly increases the levels of brain-derived neurotrophic factor (BDNF) of treated 3xTg-AD mice. In summary, our data support the idea that controlling the brain Zn(2+) homeostasis may be beneficial in the treatment of AD." @default.
• W2008980341 created "2016-06-24" @default.
• W2008980341 creator A5018941298 @default.
• W2008980341 creator A5026029366 @default.
• W2008980341 creator A5029269672 @default.
• W2008980341 creator A5055754481 @default.
• W2008980341 creator A5058319971 @default.
• W2008980341 creator A5063940108 @default.
• W2008980341 creator A5077755401 @default.
• W2008980341 creator A5079069459 @default.
• W2008980341 creator A5081337194 @default.
• W2008980341 creator A5081406568 @default.
• W2008980341 creator A5090188744 @default.
• W2008980341 date "2010-10-28" @default.
• W2008980341 modified "2023-10-10" @default.
• W2008980341 title "Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction" @default.
• W2008980341 cites W1602771322 @default.
• W2008980341 cites W1956983065 @default.
• W2008980341 cites W1965488489 @default.
• W2008980341 cites W1967464880 @default.
• W2008980341 cites W1971576287 @default.
• W2008980341 cites W1973276273 @default.
• W2008980341 cites W1977002082 @default.
• W2008980341 cites W1982961634 @default.
• W2008980341 cites W1984513006 @default.
• W2008980341 cites W1996893328 @default.
• W2008980341 cites W2000095194 @default.
• W2008980341 cites W2011965698 @default.
• W2008980341 cites W2024631202 @default.
• W2008980341 cites W2025615265 @default.
• W2008980341 cites W2043147243 @default.
• W2008980341 cites W2051516838 @default.
• W2008980341 cites W2055659156 @default.
• W2008980341 cites W2060893933 @default.
• W2008980341 cites W2065778432 @default.
• W2008980341 cites W2066110504 @default.
• W2008980341 cites W2066419835 @default.
• W2008980341 cites W2075876062 @default.
• W2008980341 cites W2077776173 @default.
• W2008980341 cites W2086333867 @default.
• W2008980341 cites W2087861584 @default.
• W2008980341 cites W2088161712 @default.
• W2008980341 cites W2097459689 @default.
• W2008980341 cites W2104773343 @default.
• W2008980341 cites W2119983609 @default.
• W2008980341 cites W2120701804 @default.
• W2008980341 cites W2129136595 @default.
• W2008980341 cites W2131181742 @default.
• W2008980341 cites W2142632602 @default.
• W2008980341 cites W2151986987 @default.
• W2008980341 cites W2154457867 @default.
• W2008980341 cites W2160212383 @default.
• W2008980341 cites W2169648500 @default.
• W2008980341 cites W2171750058 @default.
• W2008980341 cites W4296941341 @default.
• W2008980341 doi "https://doi.org/10.1038/cddis.2010.73" @default.
• W2008980341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3035902" @default.
• W2008980341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21368864" @default.
• W2008980341 hasPublicationYear "2010" @default.
• W2008980341 type Work @default.
• W2008980341 sameAs 2008980341 @default.
• W2008980341 citedByCount "155" @default.
• W2008980341 countsByYear W20089803412012 @default.
• W2008980341 countsByYear W20089803412013 @default.
• W2008980341 countsByYear W20089803412014 @default.
• W2008980341 countsByYear W20089803412015 @default.
• W2008980341 countsByYear W20089803412016 @default.
• W2008980341 countsByYear W20089803412017 @default.
• W2008980341 countsByYear W20089803412018 @default.
• W2008980341 countsByYear W20089803412019 @default.
• W2008980341 countsByYear W20089803412020 @default.
• W2008980341 countsByYear W20089803412021 @default.
• W2008980341 countsByYear W20089803412022 @default.
• W2008980341 countsByYear W20089803412023 @default.
• W2008980341 crossrefType "journal-article" @default.
• W2008980341 hasAuthorship W2008980341A5018941298 @default.
• W2008980341 hasAuthorship W2008980341A5026029366 @default.
• W2008980341 hasAuthorship W2008980341A5029269672 @default.
• W2008980341 hasAuthorship W2008980341A5055754481 @default.
• W2008980341 hasAuthorship W2008980341A5058319971 @default.
• W2008980341 hasAuthorship W2008980341A5063940108 @default.
• W2008980341 hasAuthorship W2008980341A5077755401 @default.
• W2008980341 hasAuthorship W2008980341A5079069459 @default.
• W2008980341 hasAuthorship W2008980341A5081337194 @default.
• W2008980341 hasAuthorship W2008980341A5081406568 @default.
• W2008980341 hasAuthorship W2008980341A5090188744 @default.
• W2008980341 hasBestOaLocation W20089803411 @default.
• W2008980341 hasConcept C102230213 @default.
• W2008980341 hasConcept C104317684 @default.
• W2008980341 hasConcept C126322002 @default.
• W2008980341 hasConcept C134018914 @default.
• W2008980341 hasConcept C141035611 @default.
• W2008980341 hasConcept C148762608 @default.
• W2008980341 hasConcept C160539049 @default.
• W2008980341 hasConcept C169760540 @default.
• W2008980341 hasConcept C170493617 @default.
• W2008980341 hasConcept C185592680 @default.
• W2008980341 hasConcept C207886595 @default.

• next