FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008981569> ?p ?o ?g. }

• W2008981569 abstract "Previous studies have shown that interleukin (IL)-24 as a novel tumor suppressor gene has tumor-suppressor activity in a broad spectrum of human cancer cells both in vitro and in vivo. In this study, we explored the potential effect of adenovirus-mediated IL-24 gene therapy on human hepatocellular carcinoma (HCC) by using a HCC cell line, SMMC-7721. We constructed a recombinant adenovirus, AdVGFP/IL-24 expressing the marker green fluorescent protein (GFP) and the tumor-suppressor gene, IL-24. We demonstrated that AdVGFP/IL-24 treatment of SMMC-7721 cells in vitro significantly induced HCC cell cytotoxicity and apoptosis, and altered HCC cell cycling with an S-phase reduction and G2/M phase arrest, compared with AdVGFP, without IL-24 expresssion (p < 0.05). Furthermore, we also showed that the treatment of SMMC-7721 tumors by an intratumoral injection of AdVGFP/IL-24 significantly suppressed in vivo HCC growth in athymic nude mice, compared with AdVGFP treatment (p < 0.05). In addition, we also elucidated the molecular mechanism responsible for AdVGFP/IL-24-associated tumor suppression. These include: (1) upregulation of p53-independent apoptosis-associated caspase-3 and (2) downregulation of angiogenesis-associated vascular endothelial growth factor and CD34. Therefore, this study will provide a framework for future clinical applications of AdVGFP/IL-24 in HCC gene therapy." @default.
• W2008981569 created "2016-06-24" @default.
• W2008981569 creator A5015771286 @default.
• W2008981569 creator A5053107465 @default.
• W2008981569 creator A5071965865 @default.
• W2008981569 creator A5074900624 @default.
• W2008981569 creator A5075248303 @default.
• W2008981569 date "2007-02-01" @default.
• W2008981569 modified "2023-09-27" @default.
• W2008981569 title "Adenovirus-Mediated Il-24 Expression Suppresses Hepatocellular Carcinoma Growth via Induction of Cell Apoptosis and Cycling Arrest and Reduction of Angiogenesis" @default.
• W2008981569 cites W1014535136 @default.
• W2008981569 cites W1496136136 @default.
• W2008981569 cites W1526902551 @default.
• W2008981569 cites W1572047430 @default.
• W2008981569 cites W1585683447 @default.
• W2008981569 cites W1967862898 @default.
• W2008981569 cites W1974391793 @default.
• W2008981569 cites W1979842763 @default.
• W2008981569 cites W1983366532 @default.
• W2008981569 cites W1988470304 @default.
• W2008981569 cites W1989513172 @default.
• W2008981569 cites W1999330214 @default.
• W2008981569 cites W2005581733 @default.
• W2008981569 cites W2014572862 @default.
• W2008981569 cites W2019072035 @default.
• W2008981569 cites W2022620076 @default.
• W2008981569 cites W2027776572 @default.
• W2008981569 cites W2029141733 @default.
• W2008981569 cites W2030099710 @default.
• W2008981569 cites W2030418217 @default.
• W2008981569 cites W2044816761 @default.
• W2008981569 cites W2044943819 @default.
• W2008981569 cites W2049110705 @default.
• W2008981569 cites W2054209822 @default.
• W2008981569 cites W2063993429 @default.
• W2008981569 cites W2064219151 @default.
• W2008981569 cites W2068889233 @default.
• W2008981569 cites W2074810910 @default.
• W2008981569 cites W2080632821 @default.
• W2008981569 cites W2114106497 @default.
• W2008981569 cites W2115420461 @default.
• W2008981569 cites W2127248987 @default.
• W2008981569 cites W2134003680 @default.
• W2008981569 cites W2135615816 @default.
• W2008981569 cites W2138011982 @default.
• W2008981569 cites W2163382189 @default.
• W2008981569 cites W2166105600 @default.
• W2008981569 cites W2170900458 @default.
• W2008981569 cites W2183407261 @default.
• W2008981569 cites W2234798757 @default.
• W2008981569 cites W2238881100 @default.
• W2008981569 cites W2321501275 @default.
• W2008981569 cites W2323327334 @default.
• W2008981569 cites W2410256850 @default.
• W2008981569 doi "https://doi.org/10.1089/cbr.2006.370" @default.
• W2008981569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17627414" @default.
• W2008981569 hasPublicationYear "2007" @default.
• W2008981569 type Work @default.
• W2008981569 sameAs 2008981569 @default.
• W2008981569 citedByCount "17" @default.
• W2008981569 countsByYear W20089815692012 @default.
• W2008981569 countsByYear W20089815692013 @default.
• W2008981569 countsByYear W20089815692018 @default.
• W2008981569 countsByYear W20089815692019 @default.
• W2008981569 countsByYear W20089815692022 @default.
• W2008981569 countsByYear W20089815692023 @default.
• W2008981569 crossrefType "journal-article" @default.
• W2008981569 hasAuthorship W2008981569A5015771286 @default.
• W2008981569 hasAuthorship W2008981569A5053107465 @default.
• W2008981569 hasAuthorship W2008981569A5071965865 @default.
• W2008981569 hasAuthorship W2008981569A5074900624 @default.
• W2008981569 hasAuthorship W2008981569A5075248303 @default.
• W2008981569 hasConcept C104317684 @default.
• W2008981569 hasConcept C105696609 @default.
• W2008981569 hasConcept C111599444 @default.
• W2008981569 hasConcept C121608353 @default.
• W2008981569 hasConcept C127561419 @default.
• W2008981569 hasConcept C150903083 @default.
• W2008981569 hasConcept C167734588 @default.
• W2008981569 hasConcept C190283241 @default.
• W2008981569 hasConcept C203014093 @default.
• W2008981569 hasConcept C207001950 @default.
• W2008981569 hasConcept C2777025900 @default.
• W2008981569 hasConcept C2778264664 @default.
• W2008981569 hasConcept C2780394083 @default.
• W2008981569 hasConcept C29537977 @default.
• W2008981569 hasConcept C502942594 @default.
• W2008981569 hasConcept C54355233 @default.
• W2008981569 hasConcept C55493867 @default.
• W2008981569 hasConcept C555283112 @default.
• W2008981569 hasConcept C62112901 @default.
• W2008981569 hasConcept C86803240 @default.
• W2008981569 hasConceptScore W2008981569C104317684 @default.
• W2008981569 hasConceptScore W2008981569C105696609 @default.
• W2008981569 hasConceptScore W2008981569C111599444 @default.
• W2008981569 hasConceptScore W2008981569C121608353 @default.
• W2008981569 hasConceptScore W2008981569C127561419 @default.
• W2008981569 hasConceptScore W2008981569C150903083 @default.
• W2008981569 hasConceptScore W2008981569C167734588 @default.
• W2008981569 hasConceptScore W2008981569C190283241 @default.

• next