Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008987333> ?p ?o ?g. }
- W2008987333 endingPage "8" @default.
- W2008987333 startingPage "1" @default.
- W2008987333 abstract "This paper reviews the classification of the P450 superfamily which is mainly based on sequence homology. The widely accepted classification by Nebert et al. [(1991) DNA Cell Biol. 10, 1-14] as well as the results of a ‘two-step’ multiple sequence alignment technique show that the molecular evolution of P450s, in contrast to that of many protein families, does not follow phylogeny. The data suggest that during the evolution of P450s, gene duplications and gene fusions, horizontal gene transfer and intron loss events have occurred. ‘Weak’ and ‘strong’ hierarchies in the clustering of P450 sequences were revealed. A novel evolutionary tree of the P450 superfamily has been constructed using a multiple alignment of consensus sequences. The simple classification of known P450-containing monooxygenase systems into three-, two- and one-component systems is further discussed. Particularly, the multidomain enzyme, nitric oxide synthase (NOS), should be classified as an example of a eukaryotic one-component P450 system since its N-terminal (haem) domain exhibits similarity with microsomal P450s." @default.
- W2008987333 created "2016-06-24" @default.
- W2008987333 creator A5059251330 @default.
- W2008987333 creator A5084615071 @default.
- W2008987333 date "1993-10-11" @default.
- W2008987333 modified "2023-09-24" @default.
- W2008987333 title "Molecular evolution of P450 superfamily and P450-containing monooxygenase systems" @default.
- W2008987333 cites W1238946653 @default.
- W2008987333 cites W1481415233 @default.
- W2008987333 cites W1484886979 @default.
- W2008987333 cites W1494980574 @default.
- W2008987333 cites W1508885706 @default.
- W2008987333 cites W1557514826 @default.
- W2008987333 cites W1571241687 @default.
- W2008987333 cites W1574035164 @default.
- W2008987333 cites W1969153299 @default.
- W2008987333 cites W1970613607 @default.
- W2008987333 cites W1985698599 @default.
- W2008987333 cites W1985938806 @default.
- W2008987333 cites W1990554768 @default.
- W2008987333 cites W2006352258 @default.
- W2008987333 cites W2009013636 @default.
- W2008987333 cites W2021196370 @default.
- W2008987333 cites W2030019879 @default.
- W2008987333 cites W2034767282 @default.
- W2008987333 cites W2047035909 @default.
- W2008987333 cites W2058212562 @default.
- W2008987333 cites W2060180669 @default.
- W2008987333 cites W2062042664 @default.
- W2008987333 cites W2069014655 @default.
- W2008987333 cites W2069848760 @default.
- W2008987333 cites W2075200935 @default.
- W2008987333 cites W2083209401 @default.
- W2008987333 cites W2084234371 @default.
- W2008987333 cites W2085005062 @default.
- W2008987333 cites W2092191147 @default.
- W2008987333 cites W2144739237 @default.
- W2008987333 cites W2150946709 @default.
- W2008987333 cites W2152116912 @default.
- W2008987333 cites W2495371324 @default.
- W2008987333 cites W4236006515 @default.
- W2008987333 doi "https://doi.org/10.1016/0014-5793(93)80470-f" @default.
- W2008987333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8405421" @default.
- W2008987333 hasPublicationYear "1993" @default.
- W2008987333 type Work @default.
- W2008987333 sameAs 2008987333 @default.
- W2008987333 citedByCount "100" @default.
- W2008987333 countsByYear W20089873332012 @default.
- W2008987333 countsByYear W20089873332013 @default.
- W2008987333 countsByYear W20089873332014 @default.
- W2008987333 countsByYear W20089873332015 @default.
- W2008987333 countsByYear W20089873332016 @default.
- W2008987333 countsByYear W20089873332017 @default.
- W2008987333 countsByYear W20089873332018 @default.
- W2008987333 countsByYear W20089873332019 @default.
- W2008987333 countsByYear W20089873332020 @default.
- W2008987333 countsByYear W20089873332021 @default.
- W2008987333 countsByYear W20089873332022 @default.
- W2008987333 countsByYear W20089873332023 @default.
- W2008987333 crossrefType "journal-article" @default.
- W2008987333 hasAuthorship W2008987333A5059251330 @default.
- W2008987333 hasAuthorship W2008987333A5084615071 @default.
- W2008987333 hasConcept C104317684 @default.
- W2008987333 hasConcept C13002179 @default.
- W2008987333 hasConcept C144292202 @default.
- W2008987333 hasConcept C165525559 @default.
- W2008987333 hasConcept C166393388 @default.
- W2008987333 hasConcept C167625842 @default.
- W2008987333 hasConcept C181199279 @default.
- W2008987333 hasConcept C193252679 @default.
- W2008987333 hasConcept C45484198 @default.
- W2008987333 hasConcept C526171541 @default.
- W2008987333 hasConcept C54355233 @default.
- W2008987333 hasConcept C55493867 @default.
- W2008987333 hasConcept C70721500 @default.
- W2008987333 hasConcept C78458016 @default.
- W2008987333 hasConcept C86803240 @default.
- W2008987333 hasConcept C90132467 @default.
- W2008987333 hasConcept C92938381 @default.
- W2008987333 hasConcept C94671646 @default.
- W2008987333 hasConceptScore W2008987333C104317684 @default.
- W2008987333 hasConceptScore W2008987333C13002179 @default.
- W2008987333 hasConceptScore W2008987333C144292202 @default.
- W2008987333 hasConceptScore W2008987333C165525559 @default.
- W2008987333 hasConceptScore W2008987333C166393388 @default.
- W2008987333 hasConceptScore W2008987333C167625842 @default.
- W2008987333 hasConceptScore W2008987333C181199279 @default.
- W2008987333 hasConceptScore W2008987333C193252679 @default.
- W2008987333 hasConceptScore W2008987333C45484198 @default.
- W2008987333 hasConceptScore W2008987333C526171541 @default.
- W2008987333 hasConceptScore W2008987333C54355233 @default.
- W2008987333 hasConceptScore W2008987333C55493867 @default.
- W2008987333 hasConceptScore W2008987333C70721500 @default.
- W2008987333 hasConceptScore W2008987333C78458016 @default.
- W2008987333 hasConceptScore W2008987333C86803240 @default.
- W2008987333 hasConceptScore W2008987333C90132467 @default.
- W2008987333 hasConceptScore W2008987333C92938381 @default.
- W2008987333 hasConceptScore W2008987333C94671646 @default.