FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008991566> ?p ?o ?g. }

• W2008991566 endingPage "13011" @default.
• W2008991566 startingPage "13006" @default.
• W2008991566 abstract "Successful gene therapy depends on stable transduction of hematopoietic stem cells. Target cells must cycle to allow integration of Moloney-based retroviral vectors, yet hematopoietic stem cells are quiescent. Cells can be held in quiescence by intracellular cyclin-dependent kinase inhibitors. The cyclin-dependent kinase inhibitor p15(INK4B) blocks association of cyclin-dependent kinase (CDK)4/cyclin D and p27(kip-1) blocks activity of CDK2/cyclin A and CDK2/cyclin E, complexes that are mandatory for cell-cycle progression. Antibody neutralization of beta transforming growth factor (TGFbeta) in serum-free medium decreased levels of p15(INK4B) and increased colony formation and retroviral-mediated transduction of primary human CD34(+) cells. Although TGFbeta neutralization increased colony formation from more primitive, noncycling hematopoietic progenitors, no increase in M-phase-dependent, retroviral-mediated transduction was observed. Transduction of the primitive cells was augmented by culture in the presence of antisense oligonucleotides to p27(kip-1) coupled with TGFbeta-neutralizing antibodies. The transduced cells engrafted immune-deficient mice with no alteration in human hematopoietic lineage development. We conclude that neutralization of TGFbeta, plus reduction in levels of the cyclin-dependent kinase inhibitor p27, allows transduction of primitive and quiescent hematopoietic progenitor populations." @default.
• W2008991566 created "2016-06-24" @default.
• W2008991566 creator A5005174262 @default.
• W2008991566 creator A5034279030 @default.
• W2008991566 creator A5075246076 @default.
• W2008991566 date "1998-10-27" @default.
• W2008991566 modified "2023-09-28" @default.
• W2008991566 title "Reduction in levels of the cyclin-dependent kinase inhibitor p27 ^kip-1 coupled with transforming growth factor β neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells" @default.
• W2008991566 cites W105094313 @default.
• W2008991566 cites W1277925548 @default.
• W2008991566 cites W135317861 @default.
• W2008991566 cites W1481112340 @default.
• W2008991566 cites W1481295510 @default.
• W2008991566 cites W1482247814 @default.
• W2008991566 cites W1512478116 @default.
• W2008991566 cites W1544564404 @default.
• W2008991566 cites W1908249423 @default.
• W2008991566 cites W1965200427 @default.
• W2008991566 cites W1975324295 @default.
• W2008991566 cites W1975497198 @default.
• W2008991566 cites W1987643438 @default.
• W2008991566 cites W1998739752 @default.
• W2008991566 cites W1999330214 @default.
• W2008991566 cites W2003907692 @default.
• W2008991566 cites W2006239014 @default.
• W2008991566 cites W2041972573 @default.
• W2008991566 cites W2047955220 @default.
• W2008991566 cites W2048721919 @default.
• W2008991566 cites W205272249 @default.
• W2008991566 cites W2058416269 @default.
• W2008991566 cites W2089687291 @default.
• W2008991566 cites W2089894429 @default.
• W2008991566 cites W2092104789 @default.
• W2008991566 cites W2105007068 @default.
• W2008991566 cites W2122500818 @default.
• W2008991566 cites W2145281774 @default.
• W2008991566 cites W2151091554 @default.
• W2008991566 cites W2159141578 @default.
• W2008991566 cites W2286095548 @default.
• W2008991566 cites W2398771789 @default.
• W2008991566 cites W2404754711 @default.
• W2008991566 cites W2417869212 @default.
• W2008991566 cites W2418036621 @default.
• W2008991566 cites W2418432802 @default.
• W2008991566 cites W295837541 @default.
• W2008991566 cites W72367593 @default.
• W2008991566 doi "https://doi.org/10.1073/pnas.95.22.13006" @default.
• W2008991566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/23687" @default.
• W2008991566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9789031" @default.
• W2008991566 hasPublicationYear "1998" @default.
• W2008991566 type Work @default.
• W2008991566 sameAs 2008991566 @default.
• W2008991566 citedByCount "118" @default.
• W2008991566 countsByYear W20089915662012 @default.
• W2008991566 countsByYear W20089915662013 @default.
• W2008991566 countsByYear W20089915662014 @default.
• W2008991566 countsByYear W20089915662015 @default.
• W2008991566 countsByYear W20089915662016 @default.
• W2008991566 countsByYear W20089915662018 @default.
• W2008991566 countsByYear W20089915662019 @default.
• W2008991566 countsByYear W20089915662022 @default.
• W2008991566 crossrefType "journal-article" @default.
• W2008991566 hasAuthorship W2008991566A5005174262 @default.
• W2008991566 hasAuthorship W2008991566A5034279030 @default.
• W2008991566 hasAuthorship W2008991566A5075246076 @default.
• W2008991566 hasBestOaLocation W20089915663 @default.
• W2008991566 hasConcept C109159458 @default.
• W2008991566 hasConcept C11882975 @default.
• W2008991566 hasConcept C124320809 @default.
• W2008991566 hasConcept C1491633281 @default.
• W2008991566 hasConcept C153911025 @default.
• W2008991566 hasConcept C16438837 @default.
• W2008991566 hasConcept C184235292 @default.
• W2008991566 hasConcept C201750760 @default.
• W2008991566 hasConcept C28179978 @default.
• W2008991566 hasConcept C28328180 @default.
• W2008991566 hasConcept C29537977 @default.
• W2008991566 hasConcept C502942594 @default.
• W2008991566 hasConcept C55493867 @default.
• W2008991566 hasConcept C82495950 @default.
• W2008991566 hasConcept C86803240 @default.
• W2008991566 hasConcept C94561458 @default.
• W2008991566 hasConcept C95444343 @default.
• W2008991566 hasConcept C97029542 @default.
• W2008991566 hasConceptScore W2008991566C109159458 @default.
• W2008991566 hasConceptScore W2008991566C11882975 @default.
• W2008991566 hasConceptScore W2008991566C124320809 @default.
• W2008991566 hasConceptScore W2008991566C1491633281 @default.
• W2008991566 hasConceptScore W2008991566C153911025 @default.
• W2008991566 hasConceptScore W2008991566C16438837 @default.
• W2008991566 hasConceptScore W2008991566C184235292 @default.
• W2008991566 hasConceptScore W2008991566C201750760 @default.
• W2008991566 hasConceptScore W2008991566C28179978 @default.
• W2008991566 hasConceptScore W2008991566C28328180 @default.
• W2008991566 hasConceptScore W2008991566C29537977 @default.
• W2008991566 hasConceptScore W2008991566C502942594 @default.
• W2008991566 hasConceptScore W2008991566C55493867 @default.
• W2008991566 hasConceptScore W2008991566C82495950 @default.

• next