Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009011904> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2009011904 endingPage "797" @default.
- W2009011904 startingPage "789" @default.
- W2009011904 abstract "The bg mutation in C57BL mice causes a partial impairment of NK activity, and has therefore been proposed as a model to evaluate the in vivo function of NK cells. In thepresent report, we studied natural resistance against the ascitic lines of one chemically and two virally induced syngeneic leukemias in C57BL bg/bg mice and their phenotypically normal heterozygous +/ bg littermates. S.c. threshold inocula of all three leukemia lines grew faster and caused death earlier in bg/bg than in +/bg mice, and two of the lines were rejected completely at a significantly higher frequency in +/bg control animals. The +/bg mice also eliminated [125]-IdUrd-labelled leukemia cells at a faster rate than bg/bg mice, as measured by pulmonary, hepatic and splenic radioactivity retained 18-30 h after i.v. injection Direct splenic killing of 51Cr-labelled leukemia cells was also studied in vitro, and was found to be severely depressed in bg/bg compared to +/bg. This natural killer activity was independent of adherent cells and showed a rapid, but transient, increase after inoculation of the tumor cell doses used in the transplantation tests. It was also possible to study the bg mutation in T-cell-free mice, by combining it with the nu mutation on a C57BL background. The NK activity of such beige-nude mice was found to be partially impaired compared to nude (non-beige) or wild-type animals, but higher than that of beige (non-nude) mice. Our results suggest that NK cells may be responsible for elimination of small numbers of tumor cells in the intact syngeneic host. The further use of beige and beige-nude mice in studies of transplanted and primary tumors is discussed." @default.
- W2009011904 created "2016-06-24" @default.
- W2009011904 creator A5002674606 @default.
- W2009011904 creator A5021367203 @default.
- W2009011904 creator A5028287372 @default.
- W2009011904 creator A5051391047 @default.
- W2009011904 creator A5052750275 @default.
- W2009011904 date "1980-12-15" @default.
- W2009011904 modified "2023-10-10" @default.
- W2009011904 title "In vitro NK-activity andin vivo resistance to leukemia: Studies of beige, beige/nude and wild-type hosts on C57BL background" @default.
- W2009011904 cites W1005011173 @default.
- W2009011904 cites W1514561089 @default.
- W2009011904 cites W1976161875 @default.
- W2009011904 cites W1986808562 @default.
- W2009011904 cites W1997000029 @default.
- W2009011904 cites W1998087218 @default.
- W2009011904 cites W1998881742 @default.
- W2009011904 cites W2000893197 @default.
- W2009011904 cites W2003024315 @default.
- W2009011904 cites W2003969661 @default.
- W2009011904 cites W2006974353 @default.
- W2009011904 cites W2027115443 @default.
- W2009011904 cites W2037554647 @default.
- W2009011904 cites W2039525973 @default.
- W2009011904 cites W2042081963 @default.
- W2009011904 cites W2054793269 @default.
- W2009011904 cites W2058841383 @default.
- W2009011904 cites W2063186213 @default.
- W2009011904 cites W2078361893 @default.
- W2009011904 cites W2084093106 @default.
- W2009011904 cites W2988207268 @default.
- W2009011904 cites W3020917558 @default.
- W2009011904 doi "https://doi.org/10.1002/ijc.2910260613" @default.
- W2009011904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7216547" @default.
- W2009011904 hasPublicationYear "1980" @default.
- W2009011904 type Work @default.
- W2009011904 sameAs 2009011904 @default.
- W2009011904 citedByCount "67" @default.
- W2009011904 countsByYear W20090119042023 @default.
- W2009011904 crossrefType "journal-article" @default.
- W2009011904 hasAuthorship W2009011904A5002674606 @default.
- W2009011904 hasAuthorship W2009011904A5021367203 @default.
- W2009011904 hasAuthorship W2009011904A5028287372 @default.
- W2009011904 hasAuthorship W2009011904A5051391047 @default.
- W2009011904 hasAuthorship W2009011904A5052750275 @default.
- W2009011904 hasConcept C126322002 @default.
- W2009011904 hasConcept C153911025 @default.
- W2009011904 hasConcept C202751555 @default.
- W2009011904 hasConcept C203014093 @default.
- W2009011904 hasConcept C207001950 @default.
- W2009011904 hasConcept C2777928079 @default.
- W2009011904 hasConcept C2778461978 @default.
- W2009011904 hasConcept C2780931953 @default.
- W2009011904 hasConcept C2911091166 @default.
- W2009011904 hasConcept C502942594 @default.
- W2009011904 hasConcept C54355233 @default.
- W2009011904 hasConcept C55493867 @default.
- W2009011904 hasConcept C71924100 @default.
- W2009011904 hasConcept C81885089 @default.
- W2009011904 hasConcept C86803240 @default.
- W2009011904 hasConceptScore W2009011904C126322002 @default.
- W2009011904 hasConceptScore W2009011904C153911025 @default.
- W2009011904 hasConceptScore W2009011904C202751555 @default.
- W2009011904 hasConceptScore W2009011904C203014093 @default.
- W2009011904 hasConceptScore W2009011904C207001950 @default.
- W2009011904 hasConceptScore W2009011904C2777928079 @default.
- W2009011904 hasConceptScore W2009011904C2778461978 @default.
- W2009011904 hasConceptScore W2009011904C2780931953 @default.
- W2009011904 hasConceptScore W2009011904C2911091166 @default.
- W2009011904 hasConceptScore W2009011904C502942594 @default.
- W2009011904 hasConceptScore W2009011904C54355233 @default.
- W2009011904 hasConceptScore W2009011904C55493867 @default.
- W2009011904 hasConceptScore W2009011904C71924100 @default.
- W2009011904 hasConceptScore W2009011904C81885089 @default.
- W2009011904 hasConceptScore W2009011904C86803240 @default.
- W2009011904 hasIssue "6" @default.
- W2009011904 hasLocation W20090119041 @default.
- W2009011904 hasLocation W20090119042 @default.
- W2009011904 hasOpenAccess W2009011904 @default.
- W2009011904 hasPrimaryLocation W20090119041 @default.
- W2009011904 hasRelatedWork W1749343426 @default.
- W2009011904 hasRelatedWork W2033586382 @default.
- W2009011904 hasRelatedWork W2049784275 @default.
- W2009011904 hasRelatedWork W2060358427 @default.
- W2009011904 hasRelatedWork W2083819803 @default.
- W2009011904 hasRelatedWork W2354402740 @default.
- W2009011904 hasRelatedWork W2363876635 @default.
- W2009011904 hasRelatedWork W2374622757 @default.
- W2009011904 hasRelatedWork W3025172834 @default.
- W2009011904 hasRelatedWork W2186681749 @default.
- W2009011904 hasVolume "26" @default.
- W2009011904 isParatext "false" @default.
- W2009011904 isRetracted "false" @default.
- W2009011904 magId "2009011904" @default.
- W2009011904 workType "article" @default.