Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009012922> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2009012922 endingPage "161" @default.
- W2009012922 startingPage "161" @default.
- W2009012922 abstract "The alkyl esters of p-hydroxybenzoic acid (Parabens) have been of concern due to their probable endocrine disrupting property especially in baby consumer products. The safety of parabens for use as a preservative in cosmetics has come into controversy, and thus consumer demand for paraben-free products is ever increasing. Thus, more comprehensive studies are needed to conclusively determine the safety of the multiple prolonged exposure to parabens with cosmetic ingredients. This study was conducted to investigate the potential repeated 28 days dermal toxicity (50, 100, 300, or 600 mg/kg bw/day) of isopropylparaben (IPP), isobutylparaben (IBP), or the mixture of IPP and IBP in rats. There were no significant changes in body and organ weights in any group. However, histopathological examinations showed that weak or moderate skin damages were observed in female rats by macroscopic and microscopic evaluations. In female rats, no observed adverse effect levels (NOAELs) of IPP with no skin lesion and IBP for skin hyperkeratosis, were estimated to be 600 mg/kg bw/day, and 50 mg/kg bw/day, respectively. With regard skin hyperkeratosis, the lowest observed adverse effect level (LOAEL) of the mixture of IPP and IBP was estimated to be 50 mg/kg bw/day. Analysis of six serum hormones (estrogen, testosterone, insulin, T3, TSH, or FSH) in animals showed that only FSH was dose-dependently decreased in the mixture groups of 100 mg/kg bw/day or higher. These data suggest that the mixture of IPP and IBP showed a synergistic dermal toxicity in rats and should be considered for future use in consumer products." @default.
- W2009012922 created "2016-06-24" @default.
- W2009012922 creator A5089486777 @default.
- W2009012922 date "2008-05-01" @default.
- W2009012922 modified "2023-09-26" @default.
- W2009012922 title "Letter by Namazi regarding article “Simvastatin attenuates cisplatin-induced kidney and liver damage in rats”" @default.
- W2009012922 cites W1793142484 @default.
- W2009012922 cites W1975557307 @default.
- W2009012922 cites W1990512647 @default.
- W2009012922 cites W1999615130 @default.
- W2009012922 cites W2011250217 @default.
- W2009012922 cites W2094403983 @default.
- W2009012922 cites W2113471444 @default.
- W2009012922 cites W2128865307 @default.
- W2009012922 doi "https://doi.org/10.1016/j.tox.2008.02.013" @default.
- W2009012922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18406033" @default.
- W2009012922 hasPublicationYear "2008" @default.
- W2009012922 type Work @default.
- W2009012922 sameAs 2009012922 @default.
- W2009012922 citedByCount "1" @default.
- W2009012922 countsByYear W20090129222014 @default.
- W2009012922 crossrefType "journal-article" @default.
- W2009012922 hasAuthorship W2009012922A5089486777 @default.
- W2009012922 hasConcept C126322002 @default.
- W2009012922 hasConcept C134018914 @default.
- W2009012922 hasConcept C16005928 @default.
- W2009012922 hasConcept C185592680 @default.
- W2009012922 hasConcept C2777495288 @default.
- W2009012922 hasConcept C2779279991 @default.
- W2009012922 hasConcept C2779370918 @default.
- W2009012922 hasConcept C2779915019 @default.
- W2009012922 hasConcept C29730261 @default.
- W2009012922 hasConcept C31903555 @default.
- W2009012922 hasConcept C33070731 @default.
- W2009012922 hasConcept C42407357 @default.
- W2009012922 hasConcept C46699223 @default.
- W2009012922 hasConcept C67031304 @default.
- W2009012922 hasConcept C71315377 @default.
- W2009012922 hasConcept C71924100 @default.
- W2009012922 hasConcept C86803240 @default.
- W2009012922 hasConcept C98274493 @default.
- W2009012922 hasConcept C99432707 @default.
- W2009012922 hasConceptScore W2009012922C126322002 @default.
- W2009012922 hasConceptScore W2009012922C134018914 @default.
- W2009012922 hasConceptScore W2009012922C16005928 @default.
- W2009012922 hasConceptScore W2009012922C185592680 @default.
- W2009012922 hasConceptScore W2009012922C2777495288 @default.
- W2009012922 hasConceptScore W2009012922C2779279991 @default.
- W2009012922 hasConceptScore W2009012922C2779370918 @default.
- W2009012922 hasConceptScore W2009012922C2779915019 @default.
- W2009012922 hasConceptScore W2009012922C29730261 @default.
- W2009012922 hasConceptScore W2009012922C31903555 @default.
- W2009012922 hasConceptScore W2009012922C33070731 @default.
- W2009012922 hasConceptScore W2009012922C42407357 @default.
- W2009012922 hasConceptScore W2009012922C46699223 @default.
- W2009012922 hasConceptScore W2009012922C67031304 @default.
- W2009012922 hasConceptScore W2009012922C71315377 @default.
- W2009012922 hasConceptScore W2009012922C71924100 @default.
- W2009012922 hasConceptScore W2009012922C86803240 @default.
- W2009012922 hasConceptScore W2009012922C98274493 @default.
- W2009012922 hasConceptScore W2009012922C99432707 @default.
- W2009012922 hasIssue "2-3" @default.
- W2009012922 hasLocation W20090129221 @default.
- W2009012922 hasLocation W20090129222 @default.
- W2009012922 hasOpenAccess W2009012922 @default.
- W2009012922 hasPrimaryLocation W20090129221 @default.
- W2009012922 hasRelatedWork W1421024314 @default.
- W2009012922 hasRelatedWork W187906137 @default.
- W2009012922 hasRelatedWork W1991634850 @default.
- W2009012922 hasRelatedWork W2027210979 @default.
- W2009012922 hasRelatedWork W2034630691 @default.
- W2009012922 hasRelatedWork W2043585476 @default.
- W2009012922 hasRelatedWork W2107664466 @default.
- W2009012922 hasRelatedWork W2347405960 @default.
- W2009012922 hasRelatedWork W4247442897 @default.
- W2009012922 hasRelatedWork W2411910748 @default.
- W2009012922 hasVolume "247" @default.
- W2009012922 isParatext "false" @default.
- W2009012922 isRetracted "false" @default.
- W2009012922 magId "2009012922" @default.
- W2009012922 workType "article" @default.