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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009013826> ?p ?o ?g. }

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• W2009013826 abstract "Eosinophils constitutively produce and store matrix metalloproteinase-9 (MMP-9), a protease implicated in tissue remodeling observed in asthma. In this study, we examined the rapid release of stored MMP-9 from eosinophils following stimulation with either tumor necrosis factor-alpha (TNF-alpha or the bacterial product fMLP. TNF-alpha induced rapid and robust pro-MMP-9 release from eosinophils. MMP-9 could be detected in the cell-free supernatant as early as 15min after stimulation. Rapid MMP-9 release was similarly induced by fMLP. TNF-alpha stimulation activated the mitogen-activated protein (MAP) kinases p38 MAP kinase and extracellular signal-regulated kinase-2 (Erk-2) at times and concentrations similar to that observed for MMP-9 release. Using pharmacological inhibitors, we found that TNF-alpha-stimulated MMP-9 release was mediated by p38 MAP kinase, but not Erk-1/2. Signaling through p38 MAP kinase may represent a universal mechanism for MMP-9 release from eosinophils, as fMLP-induced MMP-9 release was also regulated by p38 MAP kinase." @default.
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• W2009013826 date "2004-03-01" @default.
• W2009013826 modified "2023-10-14" @default.
• W2009013826 title "p38 MAP kinase regulates rapid matrix metalloproteinase-9 release from eosinophils" @default.
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• W2009013826 doi "https://doi.org/10.1016/j.bbrc.2004.01.078" @default.
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