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• W2009014101 abstract "The effect of phosphorothioate (PS) internucleotide linkages on the stability of phosphodiester oligodeoxyribonucleotides (ODNs) was investigated using 25-mer ODNs containing single or multiple PS backbone modifications. The in vitro stability of the oligomers was measured both in 3'-exonuclease solution and in plasma. For the separation of ODNs, capillary electrophoresis with a replaceable polymer separation matrix was used. As expected, DNA fragments with PS linkages at the 3'-end were found to be more resistant to 3'-exonuclease hydrolysis. Also increasing exonuclease resistance was the non-specific adsorption of phosphorothioate ODNs to enzyme." @default.
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• W2009014101 date "1998-08-01" @default.
• W2009014101 modified "2023-10-04" @default.
• W2009014101 title "Study of phosphorothioate-modified oligonucleotide resistance to 3′-exonuclease using capillary electrophoresis" @default.
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• W2009014101 doi "https://doi.org/10.1016/s0378-4347(98)00160-1" @default.
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