FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009016608> ?p ?o ?g. }

• W2009016608 endingPage "58" @default.
• W2009016608 startingPage "51" @default.
• W2009016608 abstract "We have established estrogen-independent and antiestrogen-resistant cell lines from hormone-dependent MCF-7 breast cancer cells by long-term culture in the absence of estrogen, or in the presence of antiestrogen toremifene, respectively. By using a cDNA microarray we compared gene expression profiles among estrogen-independent, antiestrogen-resistant and long-term estrogen-treated MCF-7 cells. We also determined how the expression of the differentially expressed genes has developed during the long-term culture of the cell lines. Of the screened 1176 cancer-related genes, FOSL1, TIMP1, L1CAM, GDF15, and MYBL2 were found to be differentially expressed between the cell lines. A change in FOSL1 and TIMP1 expression could be attributed to the development of antiestrogen resistance, whereas induced L1CAM expression was implicated in the development of estrogen-independent growth of the cells. Estrogen regulated genes GDF15 and L1CAM became regulated by toremifene in the later passage number of toremifene-resistant cells, which might be an indication of the developed estrogen-agonistic activity of toremifene in these cells. Our findings suggest a pattern where the hormone-responsive cancer cells, which survive E2 deprivation and/or antiestrogen treatment, first acquire necessary changes in gene expression for transition to maximal growth in the new hormonal environment. Then, after prolonged treatment with antiestrogen, the antiestrogen-resistant cells may eventually generate an E2-agonistic response to antiestrogen, probably acquiring additional growth advantage." @default.
• W2009016608 created "2016-06-24" @default.
• W2009016608 creator A5025536383 @default.
• W2009016608 creator A5058616699 @default.
• W2009016608 creator A5067654908 @default.
• W2009016608 date "2009-01-01" @default.
• W2009016608 modified "2023-09-27" @default.
• W2009016608 title "Gene expression changes during the development of estrogen-independent and antiestrogen-resistant growth in breast cancer cell culture models" @default.
• W2009016608 cites W1548774328 @default.
• W2009016608 cites W1873117454 @default.
• W2009016608 cites W1964527861 @default.
• W2009016608 cites W1969490406 @default.
• W2009016608 cites W1972011114 @default.
• W2009016608 cites W1975096943 @default.
• W2009016608 cites W1975960976 @default.
• W2009016608 cites W1982496758 @default.
• W2009016608 cites W1985453548 @default.
• W2009016608 cites W1997006452 @default.
• W2009016608 cites W1999444744 @default.
• W2009016608 cites W2017104941 @default.
• W2009016608 cites W2025005089 @default.
• W2009016608 cites W2026493214 @default.
• W2009016608 cites W2031709589 @default.
• W2009016608 cites W2032346433 @default.
• W2009016608 cites W2051360924 @default.
• W2009016608 cites W2065346432 @default.
• W2009016608 cites W2070417113 @default.
• W2009016608 cites W2075013638 @default.
• W2009016608 cites W2075094370 @default.
• W2009016608 cites W2108244474 @default.
• W2009016608 cites W2109388713 @default.
• W2009016608 cites W2110928253 @default.
• W2009016608 cites W2119666243 @default.
• W2009016608 cites W2128003724 @default.
• W2009016608 cites W2137355132 @default.
• W2009016608 cites W2141232624 @default.
• W2009016608 cites W2142810310 @default.
• W2009016608 cites W2144870410 @default.
• W2009016608 cites W2148320836 @default.
• W2009016608 cites W2164131844 @default.
• W2009016608 cites W2164704968 @default.
• W2009016608 cites W2169988894 @default.
• W2009016608 doi "https://doi.org/10.1097/cad.0b013e32831845e1" @default.
• W2009016608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19343000" @default.
• W2009016608 hasPublicationYear "2009" @default.
• W2009016608 type Work @default.
• W2009016608 sameAs 2009016608 @default.
• W2009016608 citedByCount "12" @default.
• W2009016608 countsByYear W20090166082012 @default.
• W2009016608 countsByYear W20090166082013 @default.
• W2009016608 countsByYear W20090166082021 @default.
• W2009016608 countsByYear W20090166082022 @default.
• W2009016608 crossrefType "journal-article" @default.
• W2009016608 hasAuthorship W2009016608A5025536383 @default.
• W2009016608 hasAuthorship W2009016608A5058616699 @default.
• W2009016608 hasAuthorship W2009016608A5067654908 @default.
• W2009016608 hasConcept C121608353 @default.
• W2009016608 hasConcept C126322002 @default.
• W2009016608 hasConcept C134018914 @default.
• W2009016608 hasConcept C2776067312 @default.
• W2009016608 hasConcept C2777164284 @default.
• W2009016608 hasConcept C2777176818 @default.
• W2009016608 hasConcept C2777637070 @default.
• W2009016608 hasConcept C502942594 @default.
• W2009016608 hasConcept C530470458 @default.
• W2009016608 hasConcept C54355233 @default.
• W2009016608 hasConcept C71924100 @default.
• W2009016608 hasConcept C84606932 @default.
• W2009016608 hasConcept C86803240 @default.
• W2009016608 hasConceptScore W2009016608C121608353 @default.
• W2009016608 hasConceptScore W2009016608C126322002 @default.
• W2009016608 hasConceptScore W2009016608C134018914 @default.
• W2009016608 hasConceptScore W2009016608C2776067312 @default.
• W2009016608 hasConceptScore W2009016608C2777164284 @default.
• W2009016608 hasConceptScore W2009016608C2777176818 @default.
• W2009016608 hasConceptScore W2009016608C2777637070 @default.
• W2009016608 hasConceptScore W2009016608C502942594 @default.
• W2009016608 hasConceptScore W2009016608C530470458 @default.
• W2009016608 hasConceptScore W2009016608C54355233 @default.
• W2009016608 hasConceptScore W2009016608C71924100 @default.
• W2009016608 hasConceptScore W2009016608C84606932 @default.
• W2009016608 hasConceptScore W2009016608C86803240 @default.
• W2009016608 hasIssue "1" @default.
• W2009016608 hasLocation W20090166081 @default.
• W2009016608 hasLocation W20090166082 @default.
• W2009016608 hasOpenAccess W2009016608 @default.
• W2009016608 hasPrimaryLocation W20090166081 @default.
• W2009016608 hasRelatedWork W1995647897 @default.
• W2009016608 hasRelatedWork W2013481652 @default.
• W2009016608 hasRelatedWork W2056607956 @default.
• W2009016608 hasRelatedWork W2068408721 @default.
• W2009016608 hasRelatedWork W2093476509 @default.
• W2009016608 hasRelatedWork W2101821182 @default.
• W2009016608 hasRelatedWork W2109882125 @default.
• W2009016608 hasRelatedWork W2150216118 @default.
• W2009016608 hasRelatedWork W2168803779 @default.
• W2009016608 hasRelatedWork W2926335606 @default.
• W2009016608 hasVolume "20" @default.

• next