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• W2009017028 endingPage "e1001112" @default.
• W2009017028 startingPage "e1001112" @default.
• W2009017028 abstract "Many genes involved in the immune response of Anopheles gambiae, the main malaria vector in Africa, have been identified, but whether naturally occurring polymorphisms in these genes underlie variation in resistance to the human malaria parasite, Plasmodium falciparum, is currently unknown. Here we carried out a candidate gene association study to identify single nucleotide polymorphisms (SNPs) associated with natural resistance to P. falciparum. A. gambiae M form mosquitoes from Cameroon were experimentally challenged with three local wild P. falciparum isolates. Statistical associations were assessed between 157 SNPs selected from a set of 67 A. gambiae immune-related genes and the level of infection. Isolate-specific associations were accounted for by including the effect of the isolate in the analysis. Five SNPs were significantly associated to the infection phenotype, located within or upstream of AgMDL1, CEC1, Sp PPO activate, Sp SNAKElike, and TOLL6. Low overall and local linkage disequilibrium indicated high specificity in the loci found. Association between infection phenotype and two SNPs was isolate-specific, providing the first evidence of vector genotype by parasite isolate interactions at the molecular level. Four SNPs were associated to either oocyst presence or load, indicating that the genetic basis of infection prevalence and intensity may differ. The validity of the approach was verified by confirming the functional role of Sp SNAKElike in gene silencing assays. These results strongly support the role of genetic variation within or near these five A. gambiae immune genes, in concert with other genes, in natural resistance to P. falciparum. They emphasize the need to distinguish between infection prevalence and intensity and to account for the genetic specificity of vector-parasite interactions in dissecting the genetic basis of Anopheles resistance to human malaria." @default.
• W2009017028 created "2016-06-24" @default.
• W2009017028 creator A5036352618 @default.
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• W2009017028 creator A5067404884 @default.
• W2009017028 creator A5071919216 @default.
• W2009017028 date "2010-09-16" @default.
• W2009017028 modified "2023-10-14" @default.
• W2009017028 title "Polymorphisms in Anopheles gambiae Immune Genes Associated with Natural Resistance to Plasmodium falciparum" @default.
• W2009017028 cites W1524651205 @default.
• W2009017028 cites W1596945931 @default.
• W2009017028 cites W1715691956 @default.
• W2009017028 cites W1964895626 @default.
• W2009017028 cites W1965933707 @default.
• W2009017028 cites W1968319638 @default.
• W2009017028 cites W1970465046 @default.
• W2009017028 cites W1971665958 @default.
• W2009017028 cites W1974871255 @default.
• W2009017028 cites W1982264720 @default.
• W2009017028 cites W1983151212 @default.
• W2009017028 cites W1984316285 @default.
• W2009017028 cites W1985376893 @default.
• W2009017028 cites W1986967891 @default.
• W2009017028 cites W1989984330 @default.
• W2009017028 cites W1992111337 @default.
• W2009017028 cites W1994181567 @default.
• W2009017028 cites W1996807624 @default.
• W2009017028 cites W1997586370 @default.
• W2009017028 cites W2002204586 @default.
• W2009017028 cites W2003124479 @default.
• W2009017028 cites W2007793421 @default.
• W2009017028 cites W2007959050 @default.
• W2009017028 cites W2008716207 @default.
• W2009017028 cites W2008808342 @default.
• W2009017028 cites W2011247119 @default.
• W2009017028 cites W2015408724 @default.
• W2009017028 cites W2021849213 @default.
• W2009017028 cites W2024453498 @default.
• W2009017028 cites W2025863286 @default.
• W2009017028 cites W2026594202 @default.
• W2009017028 cites W2027831884 @default.
• W2009017028 cites W2028773457 @default.
• W2009017028 cites W2031911789 @default.
• W2009017028 cites W2032382765 @default.
• W2009017028 cites W2033370790 @default.
• W2009017028 cites W2034857127 @default.
• W2009017028 cites W2043163382 @default.
• W2009017028 cites W2046770192 @default.
• W2009017028 cites W2047417387 @default.
• W2009017028 cites W2049900563 @default.
• W2009017028 cites W2057456254 @default.
• W2009017028 cites W2065521276 @default.
• W2009017028 cites W2070581078 @default.
• W2009017028 cites W2074506384 @default.
• W2009017028 cites W2079175200 @default.
• W2009017028 cites W2080101450 @default.
• W2009017028 cites W2082842043 @default.
• W2009017028 cites W2087780757 @default.
• W2009017028 cites W2092246095 @default.
• W2009017028 cites W2100913219 @default.
• W2009017028 cites W2101396620 @default.
• W2009017028 cites W2101418368 @default.
• W2009017028 cites W2104112516 @default.
• W2009017028 cites W2107331600 @default.
• W2009017028 cites W2108819945 @default.
• W2009017028 cites W2110065044 @default.
• W2009017028 cites W2116056464 @default.
• W2009017028 cites W2117936709 @default.
• W2009017028 cites W2118726600 @default.
• W2009017028 cites W2119964144 @default.
• W2009017028 cites W2120400028 @default.
• W2009017028 cites W2124835147 @default.
• W2009017028 cites W2125912444 @default.
• W2009017028 cites W2126526308 @default.
• W2009017028 cites W2129345640 @default.
• W2009017028 cites W2131596823 @default.
• W2009017028 cites W2146396346 @default.
• W2009017028 cites W2147532778 @default.
• W2009017028 cites W2148737023 @default.
• W2009017028 cites W2150160650 @default.
• W2009017028 cites W2159405964 @default.
• W2009017028 cites W2161278878 @default.
• W2009017028 cites W2162530578 @default.
• W2009017028 cites W2162558450 @default.
• W2009017028 cites W2165821624 @default.
• W2009017028 cites W2166238348 @default.
• W2009017028 cites W2166634100 @default.
• W2009017028 cites W2169754066 @default.
• W2009017028 cites W2172020520 @default.
• W2009017028 cites W2175405268 @default.
• W2009017028 cites W4248665920 @default.
• W2009017028 doi "https://doi.org/10.1371/journal.ppat.1001112" @default.
• W2009017028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2940751" @default.
• W2009017028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20862317" @default.

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