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• W2009024748 abstract "Annexin 2 is a Ca(2+) binding protein that binds to and aggregates secretory vesicles at physiological Ca(2+) levels [1] and that also associates Ca(2+) independently with early endosomes [2, 3]. These properties suggest roles in both exocytosis and endocytosis, but little is known of the dynamics of Annexin 2 distribution in live cells during these processes. We have used evanescent field microscopy to image Annexin 2-GFP in live, secreting rat basophilic leukemia cells and in cells performing pinocytosis. Although we found no evidence of Annexin 2 involvement in exocytosis, we observed an enrichment of Annexin 2-GFP in actin tails propeling macropinosomes. The association of Annexin 2-GFP with rocketing macropinosomes was specific because Annexin 2-GFP was absent from the actin tails of rocketing Listeria. This finding suggests that the association of Annexin 2 with macropinocytic rockets requires native pinosomal membrane. Annexin 2 is necessary for the formation of macropinocytic rockets since overexpression of a dominant-negative Annexin 2 construct abolished the formation of these structures. The same construct did not prevent the movement of Listeria in infected cells. These results show that recruitment of Annexin 2 to nascent macropinosome membranes 16656is an essential prerequisite for actin polymerization-dependent vesicle locomotion." @default.
• W2009024748 created "2016-06-24" @default.
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• W2009024748 date "2001-07-01" @default.
• W2009024748 modified "2023-10-12" @default.
• W2009024748 title "Annexin 2 has an essential role in actin-based macropinocytic rocketing" @default.
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• W2009024748 doi "https://doi.org/10.1016/s0960-9822(01)00321-9" @default.
• W2009024748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11509239" @default.
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