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- W2009035340 abstract "Background The trans-activator Tat protein is a viral regulatory protein essential for HIV-1 replication. Tat localises in both the nucleoplasm and the nucleolus. The nucleolus, a highly structured and dynamic membrane-less subnuclear compartment, is the site of rRNA and ribosome biogenesis and is involved in numerous cellular functions including transcriptional regulation, cell cycle control, RNA trafficking and viral infection. Importantly, transient nucleolar trafficking of both Tat and HIV-1 viral transcripts are critical in HIV-1 replication, however, the role(s) of the nucleolus in HIV-1 replication remains to be elucidated. To better understand how the interaction of Tat with the nucleolar machinery contributes to HIV-1 pathogenesis, we investigated the quantitative changes in the composition of the nucleolar proteome of T-cells stably expressing HIV-1 Tat. Materials and methods We employed an organellar proteomic approach using mass spectrometry coupled with Stable Isotope Labelling in Cell culture (SILAC). Identification, quantification and analysis of the purified nucleolar proteins was performed using MaxQuant, combined with Perseus, and cytoscape for pathway analysis and network reconstruction. Results" @default.
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- W2009035340 date "2011-10-03" @default.
- W2009035340 modified "2023-09-25" @default.
- W2009035340 title "Location, location, location: differential profiling of the nucleolar proteome of T-cells expressing HIV-1 Tat reveals the coordinated spatial control of distinct cellular networks" @default.
- W2009035340 doi "https://doi.org/10.1186/1742-4690-8-s2-p24" @default.
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