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- W2009042953 abstract "Despite their first recognition almost 40 years ago, CD8+ ‘suppressor’ T cells remain poorly characterized. Recent studies of these lymphocytes, now popularly referred to as regulatory CD8+ T cells (CD8+ Tregs), have helped clarify their important role in the regulation of autoimmune disease. Here, we review progress related to the identification, phenotype and function of CD8+ Tregs. We also focus on a newly described subset, CD8αα+TCRαβ+ Tregs, which in mice recognize a T-cell receptor–derived peptide in the context of the class Ib major histocompatibility complex molecule Qa-1. These Tregs target only activated T cells and complement the suppression provided by CD4+Foxp3+ Tregs. Investigations leading to the detailed identification, expansion, maintenance and function of CD8αα+ Tregs should result in new therapeutic strategies for human inflammatory diseases. Despite their first recognition almost 40 years ago, CD8+ ‘suppressor’ T cells remain poorly characterized. Recent studies of these lymphocytes, now popularly referred to as regulatory CD8+ T cells (CD8+ Tregs), have helped clarify their important role in the regulation of autoimmune disease. Here, we review progress related to the identification, phenotype and function of CD8+ Tregs. We also focus on a newly described subset, CD8αα+TCRαβ+ Tregs, which in mice recognize a T-cell receptor–derived peptide in the context of the class Ib major histocompatibility complex molecule Qa-1. These Tregs target only activated T cells and complement the suppression provided by CD4+Foxp3+ Tregs. Investigations leading to the detailed identification, expansion, maintenance and function of CD8αα+ Tregs should result in new therapeutic strategies for human inflammatory diseases." @default.
- W2009042953 created "2016-06-24" @default.
- W2009042953 creator A5052782370 @default.
- W2009042953 creator A5072512711 @default.
- W2009042953 date "2008-07-01" @default.
- W2009042953 modified "2023-10-18" @default.
- W2009042953 title "Revival of CD8+ Treg–mediated suppression" @default.
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- W2009042953 doi "https://doi.org/10.1016/j.it.2008.04.002" @default.
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