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• W2009043677 abstract "A series of charge-reversal amphiphiles with different spacers separating the headgroup from the hydrophobic chains are described for delivery of DNA and siRNA. Among them, the amphiphiles possessing a glycine spacer (e.g., B-GlyGly) showed effective DNA transfection in CHO and NIH 3T3 cells, as well as siRNA gene knockdown in HepG2 and UASMC cells. Ethidium bromide quenching assays revealed that DNA was released the fastest from the lipoplex of B-GlyGly in the presence of esterase. Also, X-ray diffraction results indicated that the DNA was located between the adjacent lipid bilayers in the lipoplex of B-GlyGly. These distinct features appear to be required for high transfection activity." @default.
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• W2009043677 date "2010-04-30" @default.
• W2009043677 modified "2023-10-18" @default.
• W2009043677 title "The Effect of Charge-Reversal Amphiphile Spacer Composition on DNA and siRNA Delivery" @default.
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• W2009043677 doi "https://doi.org/10.1021/bc9005464" @default.
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