FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009046061> ?p ?o ?g. }

• W2009046061 endingPage "44" @default.
• W2009046061 startingPage "37" @default.
• W2009046061 abstract "GABA(A) receptors containing alpha(5)-subunit have an important role in cognitive function. As the agonistic effect of 3alpha-hydroxy ring-A reduced steroids depends on subunit combinations of the GABA(A) receptor, the antagonistic effect of pregnenolone sulfate and 3beta-hydroxypregnane steroids may vary between alpha(5)-subunit and alpha(1)-subunit containing receptors. We investigated the effect of agonist and antagonist steroids in the recombinant rat alpha(1)beta(2)gamma(2L) and alpha(5)beta(2)gamma(2L) receptors expressed in Xenopus oocytes using a two electrodes voltage-clamp technique. We did not find any significant difference in potency and efficacy of GABA response between alpha(1)beta(2)gamma(2L) and alpha(5)beta(2)gamma(2L) receptors. Compared to the alpha(1)beta(2)gamma(2L) receptor, a significantly lower degree of desensitization was observed in the alpha(5)beta(2)gamma(2L) receptor. In addition, the potencies of 3alpha-OH-5alpha-pregnan-20-one (3alpha5alphaP), 5alpha-pregnan-3alpha,21-diol-20-one (3alpha5alphaTHDOC) and 5alpha-androstane-3alpha,17beta-diol (3alpha5alphaADL) to enhance GABA response were significantly higher in the alpha(5)beta(2)gamma(2L) receptor, whereas their efficacies remained unchanged between two receptors. In either receptor, the efficacy of 3alpha5alphaTHDOC was significantly higher than 3alpha5alphaP and 3alpha5alphaADL. The efficacies of 5beta-pregnan-3beta,21-diol-20-one(UC1015) and 5alpha-pregnan-3beta,20alpha-diol(UC1019) to inhibit 30 microM GABA response, and the efficacies of 3beta-OH-5beta-pregnan-20-one (UC1014) and 5beta-pregnan-3beta, 20beta-diol (UC1020) to inhibit 3 microM 3alpha5alphaTHDOC+3 microM GABA response were higher in the alpha(5)beta(2)gamma(2L) receptor compared to the alpha(1)beta(2)gamma(2L) receptor. The potencies of pregnenolone sulfate and 3beta-hydroxypregnane steroids to inhibit the GABA response and the 3alpha5alphaTHDOC+GABA response did not vary between two receptors. Interestingly, the potencies and efficacies of pregnenolone sulfate and 3beta-hydroxypregnane steroids to inhibit the GABA response were positively correlated to their potencies and efficacies to inhibit the 3alpha5alphaTHDOC+GABA response. Results from the current study revealed a different modulation pattern by neurosteroids between the alpha(1)beta(2)gamma(2L) and alpha(5)beta(2)gamma(2L) receptor." @default.
• W2009046061 created "2016-06-24" @default.
• W2009046061 creator A5013006975 @default.
• W2009046061 creator A5034600277 @default.
• W2009046061 creator A5053480244 @default.
• W2009046061 creator A5066421292 @default.
• W2009046061 creator A5067503536 @default.
• W2009046061 date "2006-10-01" @default.
• W2009046061 modified "2023-10-10" @default.
• W2009046061 title "Neurosteroid modulation of recombinant rat α5β2γ2L and α1β2γ2L GABAA receptors in Xenopus oocyte" @default.
• W2009046061 cites W1551663317 @default.
• W2009046061 cites W1957435031 @default.
• W2009046061 cites W1969104605 @default.
• W2009046061 cites W1969683921 @default.
• W2009046061 cites W1970006557 @default.
• W2009046061 cites W1970214308 @default.
• W2009046061 cites W1998236920 @default.
• W2009046061 cites W2003786364 @default.
• W2009046061 cites W2014085545 @default.
• W2009046061 cites W2022549781 @default.
• W2009046061 cites W2025250480 @default.
• W2009046061 cites W2036204342 @default.
• W2009046061 cites W2043385322 @default.
• W2009046061 cites W2055112994 @default.
• W2009046061 cites W2056802543 @default.
• W2009046061 cites W2058223478 @default.
• W2009046061 cites W2058825628 @default.
• W2009046061 cites W2062186332 @default.
• W2009046061 cites W2074990246 @default.
• W2009046061 cites W2083106679 @default.
• W2009046061 cites W2083623577 @default.
• W2009046061 cites W2095684169 @default.
• W2009046061 cites W2106001183 @default.
• W2009046061 cites W2131132003 @default.
• W2009046061 cites W2141724988 @default.
• W2009046061 cites W2165223719 @default.
• W2009046061 cites W2176076159 @default.
• W2009046061 cites W4231088280 @default.
• W2009046061 doi "https://doi.org/10.1016/j.ejphar.2006.07.039" @default.
• W2009046061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16934248" @default.
• W2009046061 hasPublicationYear "2006" @default.
• W2009046061 type Work @default.
• W2009046061 sameAs 2009046061 @default.
• W2009046061 citedByCount "28" @default.
• W2009046061 countsByYear W20090460612012 @default.
• W2009046061 countsByYear W20090460612013 @default.
• W2009046061 countsByYear W20090460612015 @default.
• W2009046061 countsByYear W20090460612016 @default.
• W2009046061 countsByYear W20090460612018 @default.
• W2009046061 countsByYear W20090460612019 @default.
• W2009046061 countsByYear W20090460612020 @default.
• W2009046061 crossrefType "journal-article" @default.
• W2009046061 hasAuthorship W2009046061A5013006975 @default.
• W2009046061 hasAuthorship W2009046061A5034600277 @default.
• W2009046061 hasAuthorship W2009046061A5053480244 @default.
• W2009046061 hasAuthorship W2009046061A5066421292 @default.
• W2009046061 hasAuthorship W2009046061A5067503536 @default.
• W2009046061 hasConcept C104317684 @default.
• W2009046061 hasConcept C126322002 @default.
• W2009046061 hasConcept C134018914 @default.
• W2009046061 hasConcept C159110408 @default.
• W2009046061 hasConcept C168258287 @default.
• W2009046061 hasConcept C170493617 @default.
• W2009046061 hasConcept C185592680 @default.
• W2009046061 hasConcept C199360897 @default.
• W2009046061 hasConcept C2775944032 @default.
• W2009046061 hasConcept C2776174256 @default.
• W2009046061 hasConcept C2776801781 @default.
• W2009046061 hasConcept C2778938600 @default.
• W2009046061 hasConcept C2779535977 @default.
• W2009046061 hasConcept C41008148 @default.
• W2009046061 hasConcept C44796713 @default.
• W2009046061 hasConcept C49453240 @default.
• W2009046061 hasConcept C55493867 @default.
• W2009046061 hasConcept C64943373 @default.
• W2009046061 hasConcept C71924100 @default.
• W2009046061 hasConcept C86803240 @default.
• W2009046061 hasConcept C9224880 @default.
• W2009046061 hasConcept C98274493 @default.
• W2009046061 hasConceptScore W2009046061C104317684 @default.
• W2009046061 hasConceptScore W2009046061C126322002 @default.
• W2009046061 hasConceptScore W2009046061C134018914 @default.
• W2009046061 hasConceptScore W2009046061C159110408 @default.
• W2009046061 hasConceptScore W2009046061C168258287 @default.
• W2009046061 hasConceptScore W2009046061C170493617 @default.
• W2009046061 hasConceptScore W2009046061C185592680 @default.
• W2009046061 hasConceptScore W2009046061C199360897 @default.
• W2009046061 hasConceptScore W2009046061C2775944032 @default.
• W2009046061 hasConceptScore W2009046061C2776174256 @default.
• W2009046061 hasConceptScore W2009046061C2776801781 @default.
• W2009046061 hasConceptScore W2009046061C2778938600 @default.
• W2009046061 hasConceptScore W2009046061C2779535977 @default.
• W2009046061 hasConceptScore W2009046061C41008148 @default.
• W2009046061 hasConceptScore W2009046061C44796713 @default.
• W2009046061 hasConceptScore W2009046061C49453240 @default.
• W2009046061 hasConceptScore W2009046061C55493867 @default.
• W2009046061 hasConceptScore W2009046061C64943373 @default.
• W2009046061 hasConceptScore W2009046061C71924100 @default.

• next