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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009046500> ?p ?o ?g. }

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• W2009046500 abstract "Here we show that in contrast to other cancer types, tumor necrosis factor (TNF)-alpha suppresses YKL-40 expression in glioma cell lines in a nuclear factor kappaB (NF-kappaB) dependent manner. Even though TNF-alpha causes recruitment of p65 and p50 subunits of NF-kappaB to the YKL-40 promoter in all cell types, recruitment of histone deacetylases (HDAC)-1 and -2, and a consequent deacetylation of histone H3 at the YKL-40 promoter occurs only in glioma cells. Importantly, using chromatin immunoprecipitation assays in frozen glioblastoma multiforme tissues, we show that YKL-40 levels decrease consistent with HDAC1 recruitment despite high levels of nuclear p-p65. This study presents a paradigm for NF-kappaB regulation of one of its targets in a strict cell type specific manner." @default.
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• W2009046500 date "2008-08-15" @default.
• W2009046500 modified "2023-10-17" @default.
• W2009046500 title "Selective repression of YKL-40 by NF-κB in glioma cell lines involves recruitment of histone deacetylase-1 and -2" @default.
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• W2009046500 doi "https://doi.org/10.1016/j.febslet.2008.08.010" @default.
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